A one pot three-component synthesis of spirooxoindoles using Cu-nanoparticles grafted on carbon microspheres as catalyst

N. S. Kaminwar, S. B. Patwari, Santosh P. Goskulwad, Santosh D. More, Sanjay K. Vyawahare, T. Pasinszki, L. Kotai, R. P. Pawar

Research output: Contribution to journalArticle


The copper nanoparticles grafted on carbon microsphere is employed for an efficient one-pot three-component synthesis of spirooxoindole derivatives involving isatin, malononitrile and enolizable ketones such as 3-methyl-1-phenyl-2-pyrazolin-5-one, 3-methyl-1-(2-chlorophenyl)-2-pyrazoline 5-one, 4-hydroxy-6-methyl-2-pyrone and 1-methyl-4-hydroxyquinoline-2-one. The cheap starting material, easy separation, high catalytic efficiency and reusability of the catalyst for several times without loss of its efficiency, good yield of products, and simple workup are promising features of the reaction in 1:1 (v/v) aqueous-alcoholic medium.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalEuropean Chemical Bulletin
Issue number5
Publication statusPublished - Jan 1 2019



  • Copper nanoparticle/C
  • Enolisable ketones
  • Heterogeneous catalyst
  • Spirooxoindoles

ASJC Scopus subject areas

  • Chemistry(all)

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