A novel way to spread drug resistance in tumor cells: Functional intercellular transfer of P-glycoprotein (ABCB1)

Suresh V. Ambudkar, Zuben E. Sauna, Michael M. Gottesman, Gergely Szakacs

Research output: Contribution to journalShort survey

66 Citations (Scopus)

Abstract

Intercellular transfer of proteins is a mode of communication between cells that is crucial for certain physiological processes. Chemotherapy is the treatment of choice for ∼50% of all cancers. However, multidrug resistance mediated by drug-efflux pumps such as P-glycoprotein (Pgp) minimizes the effectiveness of such therapy in a large number of patients. A new study demonstrates the functional intercellular transfer of Pgp. Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits.

Original languageEnglish
Pages (from-to)385-387
Number of pages3
JournalTrends in Pharmacological Sciences
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 1 2005

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ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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