A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer

Christine Wallrapp, Susanne Hähnel, Friederike Müller-Pillasch, Beata Burghardt, Takeshi Iwamura, Manuel Ruthenbürger, Markus M. Lerch, Guido Adler, Thomas M. Gress

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Abstract

We report the characterization of a novel serine protease of the chymotrypsin family, recently isolated by cDNA-representational difference analysis, as a gene overexpressed in pancreatic cancer. The 2.3-kb mRNA of the gene, named TMPRSS3, is strongly expressed in a subset of pancreatic cancer and various other cancer tissues, and its expression correlates with the metastatic potential of the clonal SUIT-2 pancreatic cancer cell lines. The deduced polypeptide sequence consists of 437 amino acids and exhibits all of the structural features characteristic of serine proteases with trypsin- like activity. TMPRSS3 is membrane bound with a NH2-terminal signal-anchor sequence and a glycosylated extracellular region containing the serine protease domain. Thus, TMPRSS3 is a novel membrane-bound serine protease overexpressed in cancer, which may be of importance for processes involved in metastasis formation and tumor invasion.

Original languageEnglish
Pages (from-to)2602-2606
Number of pages5
JournalCancer Research
Volume60
Issue number10
Publication statusPublished - May 15 2000

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wallrapp, C., Hähnel, S., Müller-Pillasch, F., Burghardt, B., Iwamura, T., Ruthenbürger, M., Lerch, M. M., Adler, G., & Gress, T. M. (2000). A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Research, 60(10), 2602-2606.