A novel specific binding site for homophthalazines in the rat brain

Edit J. Horváth, Julianna Hudák, Miklós Palkovits, Zsolt Lenkei, Márton I.K. Fekete, Péter Arányi

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Abstract

The specific binding sites of a homophthalazine, girisopam, in rat brain have been localized by qualitative and quantitative autoradiography. This substance exerts strong anxiolytic and antipsychotic effects both in rodents and in humans. High labeling was present in all major components of the extrapyramidal system, such as the caudate-putamen, globus pallidus, subthalamic nucleus, substantia nigra, and the extrapyramidal portion of the accumbens nucleus and the olfactory tubercle, while specific labeling was not seen in any other brain areas including the cerebral cortex, thalamus, cerebellum or brainstem areas. This novel distribution of girisopam is consistent with its antipsychotic effect and anxiolytic properties and may provide a morphological basis for further studies to elucidate the mechanisms of action of homophthalazines in the central nervous system.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalEuropean Journal of Pharmacology
Volume236
Issue number1
DOIs
Publication statusPublished - May 12 1993

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Keywords

  • Antipsychotic effects
  • Anxiolytic drugs
  • Homophthalazine binding (specific)

ASJC Scopus subject areas

  • Pharmacology

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