A novel plasmin-inhibitor inhibits the growth of human tumor xenografts and decreases metastasis number

Béla Szende, Yoshio Okada, Yuko Tsuda, Aniko Horvath, Gyöngyi Bökönyi, Shosuke Okamoto, Keiko Wanaka, György Kéri

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18 Citations (Scopus)

Abstract

The novel plasmin inhibitor YO-2, which also exerts an apoptosis-inducing effect on various human tumor cell cultures, was examined regarding its tumor growth inhibitory and antimetastatic action. The tumor growth inhibitory effect of YO-2 was studied using HT-29 human colon carcinoma, HT-18 human melanoma and HT-58 human B cell lymphoma inoculated as xenografts into immuno-deprived mice. Antimetastatic activity was tested on the B16 mouse melanoma muscle-lung model. YO-2 inhibited the growth of all xenografts in the range off 40-50%, when administered s.c. at a dose of 2.0 mg/kg (HT-29, HT-58) or orally at a dose of 0.4 mg/kg (HT-18). YO-2 decreased the number of lung metastasis found in mice inoculated i.m. with B16 melanoma, 4 mg/kg being the most effective. Since YO-2 is the only plasmin inhibitor having antihemorrhagic and also antitumor effect, this compound could be rationally used in combination therapy of neoplastic disease, especially when hemorrhage aggravates the course of the disease.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalIn Vivo
Volume16
Issue number5
Publication statusPublished - Sep 1 2002

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Keywords

  • Anti-tumor
  • Plasmin-inhibitor
  • Tumor xenograft
  • metastasis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Szende, B., Okada, Y., Tsuda, Y., Horvath, A., Bökönyi, G., Okamoto, S., Wanaka, K., & Kéri, G. (2002). A novel plasmin-inhibitor inhibits the growth of human tumor xenografts and decreases metastasis number. In Vivo, 16(5), 281-286.