A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart

Hanne Luosujrvi, Jani Aro, Heikki Tokola, Hanna Leskinen, Olli Tenhunen, Réka Skoumal, Istvn Szokodi, Heikki Ruskoaho, Jaana Rys

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dyxin is a novel LIM domain protein acting as a transcriptional cofactor with GATA transcription factors. Here, we characterized dyxin as a p38 mitogen-activated protein kinase (MAPK) regulated gene, since combined upstream MAPK kinase 3b and wild-type p38α MAPK gene transfer increased left ventricular dyxin mRNA and protein levels in vivo. We also studied cardiac dyxin expression in experimental models of pressure overload and myocardial infarction (MI) in vivo. Angiotensin II infusion increased left ventricular dyxin mRNA levels (9.4-fold, p

Original languageEnglish
Pages (from-to)54-63
Number of pages10
JournalBlood Pressure
Volume19
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

p38 Mitogen-Activated Protein Kinases
LIM Domain Proteins
GATA Transcription Factors
Messenger RNA
Mitogen-Activated Protein Kinase Kinases
Angiotensin II
Genes
Theoretical Models
Myocardial Infarction
Pressure
Proteins

Keywords

  • Cardiac hypertrophy
  • Lmcd1
  • Myocardial infarction
  • P38 MAPK
  • Pressure overload
  • Remodeling

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Luosujrvi, H., Aro, J., Tokola, H., Leskinen, H., Tenhunen, O., Skoumal, R., ... Rys, J. (2010). A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart. Blood Pressure, 19(1), 54-63. https://doi.org/10.3109/08037050903464519

A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart. / Luosujrvi, Hanne; Aro, Jani; Tokola, Heikki; Leskinen, Hanna; Tenhunen, Olli; Skoumal, Réka; Szokodi, Istvn; Ruskoaho, Heikki; Rys, Jaana.

In: Blood Pressure, Vol. 19, No. 1, 2010, p. 54-63.

Research output: Contribution to journalArticle

Luosujrvi, H, Aro, J, Tokola, H, Leskinen, H, Tenhunen, O, Skoumal, R, Szokodi, I, Ruskoaho, H & Rys, J 2010, 'A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart', Blood Pressure, vol. 19, no. 1, pp. 54-63. https://doi.org/10.3109/08037050903464519
Luosujrvi, Hanne ; Aro, Jani ; Tokola, Heikki ; Leskinen, Hanna ; Tenhunen, Olli ; Skoumal, Réka ; Szokodi, Istvn ; Ruskoaho, Heikki ; Rys, Jaana. / A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart. In: Blood Pressure. 2010 ; Vol. 19, No. 1. pp. 54-63.
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