A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones

Árpád Balázs, Erik Van der Eycken, Ferenc Fülöp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed, microwave-assisted intramolecular condensation step.

Original languageEnglish
Pages (from-to)4333-4335
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number28
DOIs
Publication statusPublished - Jul 7 2008

Keywords

  • 1,4-Diazepin-5-one
  • Microwave
  • Oxidative cleavage
  • β-Amino acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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