A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

Péter Polyák, Dóra Szemerszki, Henrik Christopher Benke, B. Pukánszky

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalPolymer Testing
Volume63
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Hydroxybutyrates
Color
Polymer films
Permeation
Pharmaceutical Preparations
Calibration
Wavelength
poly-beta-hydroxybutyrate

Keywords

  • Concentration gradient
  • Diffusion
  • Dissolution
  • Fick's laws
  • Measurement of color
  • PHB film

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics

Cite this

A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate). / Polyák, Péter; Szemerszki, Dóra; Benke, Henrik Christopher; Pukánszky, B.

In: Polymer Testing, Vol. 63, 01.10.2017, p. 342-348.

Research output: Contribution to journalArticle

Polyák, Péter ; Szemerszki, Dóra ; Benke, Henrik Christopher ; Pukánszky, B. / A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate). In: Polymer Testing. 2017 ; Vol. 63. pp. 342-348.
@article{b2f9092d81054cb3b387bc1fa2b5ea74,
title = "A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)",
abstract = "A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time.",
keywords = "Concentration gradient, Diffusion, Dissolution, Fick's laws, Measurement of color, PHB film",
author = "P{\'e}ter Poly{\'a}k and D{\'o}ra Szemerszki and Benke, {Henrik Christopher} and B. Puk{\'a}nszky",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.polymertesting.2017.08.037",
language = "English",
volume = "63",
pages = "342--348",
journal = "Polymer Testing",
issn = "0142-9418",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

AU - Polyák, Péter

AU - Szemerszki, Dóra

AU - Benke, Henrik Christopher

AU - Pukánszky, B.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time.

AB - A novel approach is proposed for the determination of the diffusion coefficient of certain drugs in amorphous poly(hydroxybutyrate) (PHB), which can be a reliable alternative to the conventional permeation based measurements. The method requires the preparation of PHB films with various concentrations of the drug and if the latter absorbs in the visible wavelength range, its concentration gradient in the polymer film as well as the time dependence of the latter can be analyzed quantitatively by following changes in color. Color can be converted into concentration with the help of adequate calibration and thus the dependence of additive concentration on space (x) and time (t), i.e. the c(x,t) function, can be determined relatively easily. The fitting of the numerical solution of Fick's second law onto the measured values provides directly the targeted diffusion coefficient. The comparison of diffusion coefficients obtained by the proposed approach to values published in the literature proved that the new method provides reliable results and requires reasonable time and effort at the same time.

KW - Concentration gradient

KW - Diffusion

KW - Dissolution

KW - Fick's laws

KW - Measurement of color

KW - PHB film

UR - http://www.scopus.com/inward/record.url?scp=85028733935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028733935&partnerID=8YFLogxK

U2 - 10.1016/j.polymertesting.2017.08.037

DO - 10.1016/j.polymertesting.2017.08.037

M3 - Article

AN - SCOPUS:85028733935

VL - 63

SP - 342

EP - 348

JO - Polymer Testing

JF - Polymer Testing

SN - 0142-9418

ER -