A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics

Zsuzsanna Literati-Nagy, Kálmán Tory, Botond Literáti-Nagy, Attila Kolonics, László Vígh, László Vígh, József Mandl, Zoltán Szilvássy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Atypical antipsychotic drugs (AAPD) are widely used to treat severe psychiatric disorders, have well documented metabolic side effects such as disturbances in glucose metabolism, insulin resistance and weight gain. It has been shown that BGP-15, a hydroxylamine derivative with insulin sensitizing activity can prevent AAPD provoked fat accumulation in adipocyte cultures, and insulin resistance in animal experiments and in healthy volunteers. The aim of this study was to compare the preventive effect of BGP-15 with conventional oral antidiabetics on metabolic side effects of AAPDs. We found that BGP-15 that does not belong to either conventional insulin sensitizers or oral antidiabetics, is able to counteract insulin resistance and weight gain provoked by antipsychotic agents in rats while rosiglitazone and metformin were not effective in the applied doses. Our results confirm that BGP-15 is a promising new drug candidate to control the metabolic side effects of atypical antipsychotics. Data indicate that this rat model is suitable to analyze the metabolic side effects of AAPDs and the protective mechanism of BGP-15.

Original languageEnglish
Pages (from-to)1071-1076
Number of pages6
JournalPathology and Oncology Research
Volume18
Issue number4
DOIs
Publication statusPublished - Oct 1 2012

Keywords

  • Atypical antipsychotic drugs
  • BGP-15
  • Hydroxylamine derivative
  • Hyperinsulinaemic euglycaemic glucose clamp
  • Insulin resistance
  • Side effects
  • Weight gain

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'A novel insulin sensitizer drug candidate-BGP-15-can prevent metabolic side effects of atypical antipsychotics'. Together they form a unique fingerprint.

  • Cite this