A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis

Zsuzsanna Pál, Péter Antal, András Millinghoffer, Gábor Hullám, Krisztina Pálóczi, Sára Tóth, Hans Joachim Gabius, Mária Judit Molnár, András Falus, Edit Irén Buzás

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Galectin-1 (LGALS1) and interleukin receptor 2β (IL2Rβ) are regulators of T-cell activation. Here we evaluated the association of regulatory region polymorphisms of the LGALS1 (rs4820293, rs4820294) and IL2Rβ (rs743777, rs228941) genes in 146 Caucasian myasthenia gravis patients compared to 291 ethnically matched controls. A significant difference was found in the distribution of the rs4820293/rs743777 polymorphism haplotypes (p<0.01). The rs4820293 polymorphism, previously not described to be associated with any disease, does not affect LGALS1 expression in peripheral mononuclear cells and skeletal muscle. Pathway analysis revealed interaction between LGALS1 and IL2Rβ suggesting a role of these proteins in this rare disease.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Neuroimmunology
Volume229
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2010

Keywords

  • LGALS1
  • Myasthenia
  • SNP

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis'. Together they form a unique fingerprint.

  • Cite this