A novel concept of treatment in MS: Targeting both oligodendrocyte death and inflammatory processes by inhibiting poly(adp-ribose) polymerase

Zsolt Illes, Hans Lassmann, Ferenc Gallyas

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The pathology of multiple sclerosis (MS) was originally defined by inflammation, focal primary demyelination in the white matter, and astrocytic gliosis. This plaque-centered view of MS pathology has been revised during the last years (Lassmann et al. Brain Pathol 17:210-218, 2007). It became clear that pathology is not restricted to focal white matter lesions, but that demyelination may also affect the gray matter, most prominently the cerebral and cerebellar cortex (Peterson et al. Ann Neurol 50:389-400, 2001; Kutzelnigg et al. Brain 128:2705-2712, 2005)

Original languageEnglish
Title of host publicationMultiple Sclerosis Immunology
Subtitle of host publicationA Foundation for Current and Future Treatments
PublisherSpringer New York
Pages315-340
Number of pages26
ISBN (Electronic)9781461479536
ISBN (Print)1461479525, 9781461479529
DOIs
Publication statusPublished - Nov 1 2013

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Illes, Z., Lassmann, H., & Gallyas, F. (2013). A novel concept of treatment in MS: Targeting both oligodendrocyte death and inflammatory processes by inhibiting poly(adp-ribose) polymerase. In Multiple Sclerosis Immunology: A Foundation for Current and Future Treatments (pp. 315-340). Springer New York. https://doi.org/10.1007/978-1-4614-7953-6_15