A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp

Yang Liu, T. Kurtán, Attila Mándi, Horst Weber, Changyun Wang, Rudolf Hartmann, Wenhan Lin, Georgios Daletos, Peter Proksch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel 10-membered macrolactone, hypoxylide (1), was isolated from the endophytic fungus Annulohypoxylon sp. that was obtained from the Mangrove plant Rhizophora racemosa. The structure and absolute configuration of 1 were unambiguously elucidated by comprehensive 1D and 2D NMR, as well as by HRESIMS and ECD spectroscopic analyses. Hypoxylide (1) features an unprecedented polyketide skeleton comprised of a trihydroxynaphthalene-dione moiety fused to a decalactone ring. A plausible biosynthetic pathway of this novel metabolite is proposed.

Original languageEnglish
JournalTetrahedron Letters
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Rhizophoraceae
Polyketides
Biosynthetic Pathways
Lactones
Metabolites
Fungi
Skeleton
Nuclear magnetic resonance

Keywords

  • Annulohypoxylon sp.
  • Endophytic fungus
  • Macrolactone
  • Mangrove
  • Natural product

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp. / Liu, Yang; Kurtán, T.; Mándi, Attila; Weber, Horst; Wang, Changyun; Hartmann, Rudolf; Lin, Wenhan; Daletos, Georgios; Proksch, Peter.

In: Tetrahedron Letters, 01.01.2018.

Research output: Contribution to journalArticle

Liu, Yang ; Kurtán, T. ; Mándi, Attila ; Weber, Horst ; Wang, Changyun ; Hartmann, Rudolf ; Lin, Wenhan ; Daletos, Georgios ; Proksch, Peter. / A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp. In: Tetrahedron Letters. 2018.
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