A histidine regulatory mutant was isolated from Escherichia coli K12. This mutant has some characteristic features, which are different from those of Salmonella typhimurium regulatory mutants: i/ normal colony morphology, normal growth even at 43°C. ii/ the level of histidine biosynthetic enzymes is temperature dependent, high /22-25 times the wild type/ levels being attained at high temperatures. Following a period of leucine starvation there is a burst of enzyme synthesis, when leucine is readded.
|Number of pages||6|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - Jun 18 1971|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology