A new type of histidine regulatory mutant in Escherichia coli

L. Patthy, G. Dénes

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A histidine regulatory mutant was isolated from Escherichia coli K12. This mutant has some characteristic features, which are different from those of Salmonella typhimurium regulatory mutants: i/ normal colony morphology, normal growth even at 43°C. ii/ the level of histidine biosynthetic enzymes is temperature dependent, high /22-25 times the wild type/ levels being attained at high temperatures. Following a period of leucine starvation there is a burst of enzyme synthesis, when leucine is readded.

Original languageEnglish
Pages (from-to)1246-1251
Number of pages6
JournalBiochemical and biophysical research communications
Issue number6
Publication statusPublished - Jun 18 1971


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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