A new trichothecin-like antifungal antibiotic

E. Gláz, Eszter Scheiber, J. Gyimesi, I. Horvath, Katalin Steczek, A. Szentirmai, G. Bohus

Research output: Contribution to journalArticle

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Abstract

IN a screening programme for antibiotic effects of Basidiomycetes we found a strain which inhibited Candida albicans. The antifungal substance was produced by this strain in surface and submerged culture in a medium containing peptone, glucose, inorganic salts and aneurin. The substance for which we provisionally propose the name 'antibiotic-T' was easily extracted from the fermentation liquor by most of the usual solvents. After extraction with benzene and evaporation of the solvent the residue became crystalline within a few days. Recrystallization twice from methyl alcohol gave pure crystals (prisms), melting point 126°C.,[α]D20 + 13.5°, c. 1 in chloroform. No ultra-violet absorption characteristic of antifungal antibiotics of the polyene type was found. The antibiotic contains no halogen, sulphur or nitrogen. Micro-analyses: found (per cent): carbon, 68.51; hydrogen, 7.6; and oxygen, 25.0. The substance is very slightly soluble in hot water and gives a neutral solution; it is soluble in alcohols and sunflower oil and readily soluble in non-polar solvents. Its solution in water is stable for two months, is thermo-stable at its boiling point, but is inactivated at pH 12 within a few hours.

Original languageEnglish
Pages (from-to)908
Number of pages1
JournalNature
Volume184
Issue number4690
DOIs
Publication statusPublished - 1959

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Antifungal Agents
Anti-Bacterial Agents
Polyenes
Basidiomycota
Peptones
Halogens
Water
Thiamine
Chloroform
Benzene
Candida albicans
Sulfur
Freezing
Fermentation
Names
Methanol
Hydrogen
Nitrogen
Carbon
Salts

ASJC Scopus subject areas

  • General

Cite this

Gláz, E., Scheiber, E., Gyimesi, J., Horvath, I., Steczek, K., Szentirmai, A., & Bohus, G. (1959). A new trichothecin-like antifungal antibiotic. Nature, 184(4690), 908. https://doi.org/10.1038/184908a0

A new trichothecin-like antifungal antibiotic. / Gláz, E.; Scheiber, Eszter; Gyimesi, J.; Horvath, I.; Steczek, Katalin; Szentirmai, A.; Bohus, G.

In: Nature, Vol. 184, No. 4690, 1959, p. 908.

Research output: Contribution to journalArticle

Gláz, E, Scheiber, E, Gyimesi, J, Horvath, I, Steczek, K, Szentirmai, A & Bohus, G 1959, 'A new trichothecin-like antifungal antibiotic', Nature, vol. 184, no. 4690, pp. 908. https://doi.org/10.1038/184908a0
Gláz E, Scheiber E, Gyimesi J, Horvath I, Steczek K, Szentirmai A et al. A new trichothecin-like antifungal antibiotic. Nature. 1959;184(4690):908. https://doi.org/10.1038/184908a0
Gláz, E. ; Scheiber, Eszter ; Gyimesi, J. ; Horvath, I. ; Steczek, Katalin ; Szentirmai, A. ; Bohus, G. / A new trichothecin-like antifungal antibiotic. In: Nature. 1959 ; Vol. 184, No. 4690. pp. 908.
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