For solid‐phase peptide synthesis, 2, 4‐dimethoxy‐4′ ‐hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2, 4‐dimethoxy‐4′‐hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.
|Number of pages||2|
|Journal||International journal of peptide and protein research|
|Publication status||Published - Jan 1994|
- potassium salt coupling of phenolate
- side reactions
- substitution level
ASJC Scopus subject areas