A new synthesis of Rink's polymer, 4‐(2′,4′‐dimethoxyphenylhydroxymethyl) phenoxymethylpolystyrene

GYÖRGYI VÁRADI, GÁBOR K. TÓTH, BOTOND PENKE

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For solid‐phase peptide synthesis, 2, 4‐dimethoxy‐4′ ‐hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2, 4‐dimethoxy‐4′‐hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.

Original languageEnglish
Pages (from-to)29-30
Number of pages2
JournalInternational journal of peptide and protein research
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 1994

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Keywords

  • 2,4‐dimethoxy‐4′‐hydroxybenzhydrol
  • potassium salt coupling of phenolate
  • side reactions
  • substitution level

ASJC Scopus subject areas

  • Biochemistry

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