A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene

G. Varadi, G. Tóth, B. Penke

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.

Original languageEnglish
Pages (from-to)29-30
Number of pages2
JournalInternational Journal of Peptide and Protein Research
Volume43
Issue number1
Publication statusPublished - 1994

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Salts
Cesium
Solid-Phase Synthesis Techniques
Potassium
Polymers
Substitution reactions
Peptides
Rink's polymer
4-hydroxybenzophenone
lithium borohydride

Keywords

  • 2,4-dimethoxy-4'-hydroxybenzhydrol
  • potassium salt coupling of phenolate
  • side reactions
  • substitution level

ASJC Scopus subject areas

  • Biochemistry

Cite this

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abstract = "For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.",
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T1 - A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene

AU - Varadi, G.

AU - Tóth, G.

AU - Penke, B.

PY - 1994

Y1 - 1994

N2 - For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.

AB - For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxybenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenzophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.

KW - 2,4-dimethoxy-4'-hydroxybenzhydrol

KW - potassium salt coupling of phenolate

KW - side reactions

KW - substitution level

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