A new synthesis of C-β-d-glycopyranosylmethyl sulfides by metal-free coupling of anhydro-aldose tosylhydrazones with thiols

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Abstract

Herein, cross coupling reactions of O-peracylated 2,6-anhydro-aldose tosylhydrazones with aliphatic, (hetero)aromatic, and sugar-derived thiols were studied under thermal conditions in the presence of K3PO4. The reactions with aliphatic thiols provided the corresponding C-β-d-glycopyranosylmethyl sulfides in 20-50% yields, whereas the reactions with thiophenols gave the corresponding sulfides in 50-80% yields. On the other hand, sugar-derived thiols failed to yield the expected compounds with acceptable selectivity. The transformations present a new access to these types of glycomimetic compounds. The method is complementary to thiol-ene additions of exo-glycals (also obtained from the abovementioned tosylhydrazones) that provide good yields of aliphatic and sugar-derived C-glycosylmethyl sulfides. Thus, anhydro-aldose tosylhydrazones serve as a common starting material towards any kind of C-glycosylmethyl sulfide type target compounds either in a direct coupling reaction or in thiol-ene additions of exo-glycals.

Original languageEnglish
Pages (from-to)13871-13880
Number of pages10
JournalNew Journal of Chemistry
Volume41
Issue number22
DOIs
Publication statusPublished - Jan 1 2017

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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