A new synthesis of 3,5-diaryl-pyrrole-2-carboxylic acids and esters

Imre Fejes, László Toke, Gábor Blaskó, Miklós Nyerges, Chwang Siek Pak

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30 Citations (Scopus)

Abstract

A new two-step synthesis of pyrrole-2-carboxylic acids, steps via 1,3 dipolar cycloaddition of azomethine ylides to nitro-styrenes and oxidation of the resulting pyrrolidines with alkaline hydrogen peroxide is described. The oxidation of cycloadducts 3 by the means of MnO2 under different conditions also has been examined. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)8545-8553
Number of pages9
JournalTetrahedron
Volume56
Issue number43
DOIs
Publication statusPublished - Oct 20 2000

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Keywords

  • Cycloadditions
  • Oxidation
  • Pyrroles
  • Pyrrolidines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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