A new strategy to produce β-peptides: Use of alicyclic β-lactams

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

(Chemical Equation Presented) On p-methylbenzhydrylamine (MBHA) resin, by means of t-Boc chemistry, several tetrapeptides (H-Ala-ACXC-Ala-Gly-NH 2) containing cyclic β-amino acid units were prepared. These units were introduced into the growing peptide chain by using Boc-protected β-lactams with KCN as catalyst in DMF. The method was applicable for both racemic and enantiomeric β-lactams.

Original languageEnglish
Pages (from-to)4239-4241
Number of pages3
JournalOrganic Letters
Volume6
Issue number23
Publication statusPublished - Nov 11 2004

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Lactams
resins
peptides
amino acids
Cyclic Amino Acids
alanylglycine
chemistry
catalysts
Peptides
Resins
Catalysts

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

A new strategy to produce β-peptides : Use of alicyclic β-lactams. / Fülöp, F.; Forró, E.; Tóth, G.

In: Organic Letters, Vol. 6, No. 23, 11.11.2004, p. 4239-4241.

Research output: Contribution to journalArticle

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