A new strategy for the regio- and stereoselective hydroxylation of trans-2-aminocyclohexenecarboxylic acid

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A simple and novel method for the introduction of an extra hydroxy group into an aminocyclohexanecarboxylic acid via stereoselective epoxidation and regioselective opening of the oxirane ring is presented. This method permits the preparation of the enantiomerically pure hydroxylated amino acid.

Original languageEnglish
Pages (from-to)2855-2858
Number of pages4
JournalTetrahedron Letters
Issue number17
Publication statusPublished - Apr 24 2006



  • Cyclic β-amino acids
  • Enzymatic resolution
  • Epoxidation
  • Hydroxylated amino acids
  • Selective synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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