A new route, jet injection for anesthetic induction in children - III. Ketamine pharmacokinetic studies

E. F. Domino, E. K. Zsigmond, V. Kovacs, G. Fekete, P. Stetson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The jet injector route for ketamine was used on 30 children 1-6 years of age undergoing various surgical procedures. A randomly selected dose of 2.5, 3.5, or 6.0 mg/kg of ketamine was given to induce anesthesia. Peak plasma ketamine levels did not follow a simple arithmetic increment related to dose. Dosage based on mg/m2 body surface area or mg/kg body weight provided similar blood levels of ketamine. The β-phase t(1/2) of ketamine in these children was shorter than that found in adults. Considerable individual variability was observed in both the plasma levels to a given dose of jet-injected ketamine and in the β-phase t(1/2). The ketamine β-t(1/2)s were not dose related.

Original languageEnglish
Pages (from-to)527-530
Number of pages4
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume35
Issue number11
Publication statusPublished - 1997

Keywords

  • Jet injection
  • Ketamine pharmacokinetics
  • Pediatric anesthesia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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