A new model for the study of opiate B-receptors: Isolated splenic strip of the cat

L. Kerecsen, J. Knoll

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Abstract

Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptors. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more potent than naloxone in this organ, the cat splenic strip is a useful model for the in vitro testing of opiate B-receptors.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalPharmacology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 1981

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ASJC Scopus subject areas

  • Pharmacology

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