A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy

László Molnár, Katalin Hegedüs, I. Fekete

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An artificial ball removable by an attached fiber was injected into the middle cerebral artery (MCA) of 16 rabbits, allowing the study of transient (5, 10, 15, or 30 minutes) cerebral ischemia without craniectomy. Measurements of available oxygen (ao2) in the ischemic core (the ventral part of the temporal area) followed by histologic examination verified the embolization. Electroencephalographic power spectra and steady (direct current) potentials were recorded bilaterally on the convexity remote from the actual lesion but still supplied by the MCA. Local cerebral blood flow and ao2 in the border zone between the anterior cerebral artery and the occluded MCA were measured. Embolization caused typical ischemic changes ipsilaterally and alterations characteristic of diaschisis contralaterally. Extreme border zone hyperemia developed without significant ao2 changes in the same region. Restoration of circulation via the circle of Willis induced gradual normalization. Our model for controlled embolization and recirculation proved suitable for detailed studies of the complex changes in brain function caused by transient ischemia.

Original languageEnglish
Pages (from-to)1262-1266
Number of pages5
JournalStroke
Volume19
Issue number10
Publication statusPublished - 1988

Fingerprint

Transient Ischemic Attack
Middle Cerebral Artery
Reperfusion
Rabbits
Cerebrovascular Circulation
Circle of Willis
Anterior Cerebral Artery
Hyperemia
Brain Ischemia
Ischemia
Oxygen
Brain

Keywords

  • Cerebral ischemia
  • Embolization
  • Rabbits

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

Cite this

A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. / Molnár, László; Hegedüs, Katalin; Fekete, I.

In: Stroke, Vol. 19, No. 10, 1988, p. 1262-1266.

Research output: Contribution to journalArticle

Molnár, László ; Hegedüs, Katalin ; Fekete, I. / A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. In: Stroke. 1988 ; Vol. 19, No. 10. pp. 1262-1266.
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