A new hypothesis on the role of vessel topology in cerebral aneurysm initiation

Benjamin Csippa, Gábor Závodszky, György Paál, I. Szikora

Research output: Contribution to journalArticle

1 Citation (Scopus)


Aneurysm pathogenesis is thought to be strongly linked with hemodynamical effects. According to our current knowledge, the formation process is initiated by locally disturbed flow conditions. The aim of the current work is to provide a numerical investigation on the role of the flow field at the stage of the initiation, before the aneurysm formation. Digitally reconstructed pre-aneurysmal geometries are used to examine correlations of the flow patterns to the location and direction of the aneurysms formed later. We argue that a very specific rotational flow pattern is present in all the investigated cases marking the location of the later aneurysm and that these flow patterns provide the mechanical load on the wall that can lead to a destructive remodelling in the vessel wall. Furthermore, these patterns induce elevated vessel surface related variables (e.g. wall shear stress (WSS), wall shear stress gradient (WSSG) and oscillatory shear index (OSI)), in agreement with the previous findings. We emphasise that the analysis of the flow patterns provides a deeper insight and a more robust numerical methodology compared to the sole examination of the aforementioned surface quantities.

Original languageEnglish
Pages (from-to)244-251
Number of pages8
JournalComputers in Biology and Medicine
Publication statusPublished - Dec 1 2018


  • Aneurysm initiation
  • CFD
  • Endothelial layer
  • Pathogenesis
  • Reconstruction
  • Secondary flow
  • WSS

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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