A new facile synthesis of steroid dimers containing 17,17′- dicarboxamide spacers

Rui M B Carrilho, Mariette M. Pereira, Maria José S M Moreno, Attila Takács, L. Kollár

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A set of new steroid dimers linked through ring D-ring D were synthesized via catalytic diaminocarbonylation of 17-iodo-5α-androst-16-ene, in the presence of palladium-phosphine in situ catalysts and aliphatic or aromatic diamines as N-nucleophiles. The dimeric steroidal compounds containing 17,17′-dicarboxamide spacers were obtained through highly chemoselective reactions in good isolated yields and completely characterized by spectroscopic techniques.

Original languageEnglish
Pages (from-to)2763-2765
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number22
DOIs
Publication statusPublished - May 29 2013

Fingerprint

phosphine
Nucleophiles
Diamines
Palladium
Dimers
Steroids
Catalysts
16-androstene
compound 17

Keywords

  • Carbon monoxide
  • Carbonylation
  • Diamine
  • Palladium
  • Steroid dimmers

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A new facile synthesis of steroid dimers containing 17,17′- dicarboxamide spacers. / Carrilho, Rui M B; Pereira, Mariette M.; Moreno, Maria José S M; Takács, Attila; Kollár, L.

In: Tetrahedron Letters, Vol. 54, No. 22, 29.05.2013, p. 2763-2765.

Research output: Contribution to journalArticle

Carrilho, Rui M B ; Pereira, Mariette M. ; Moreno, Maria José S M ; Takács, Attila ; Kollár, L. / A new facile synthesis of steroid dimers containing 17,17′- dicarboxamide spacers. In: Tetrahedron Letters. 2013 ; Vol. 54, No. 22. pp. 2763-2765.
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