A new cyclitol derivative influences inositol metabolism in Neurospora crassa

G. Szabó, M. Schablik, Á Kiss, Cs Koncz, R. Bognár, I. Pelyvás, F. Sztaricskai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S, 3R, 5R)-3-azido-2-benzoyloxy-5-hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa. In Neurospora crassa it increased the amount of myo-inositol-1-phosphate synthase and inhibited the activity of myo-inositol-monophosphatase. The enhanced synthesis of myo-inositol-1-phosphate synthase was the consequence of lowering the intracellular inositol concentration. Li+ treatment of Neurospora crassa has effects similar to those of P.I.-658.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalFEMS microbiology letters
Volume82
Issue number1
Publication statusPublished - Jul 15 1991

Keywords

  • Cyclitol derivative
  • Inositol metabolism
  • Neurospora crassa

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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    Szabó, G., Schablik, M., Kiss, Á., Koncz, C., Bognár, R., Pelyvás, I., & Sztaricskai, F. (1991). A new cyclitol derivative influences inositol metabolism in Neurospora crassa. FEMS microbiology letters, 82(1), 15-18.