A new computer model of mitral valve hemodynamics during ventricular filling

Gábor Szabó, Davis Soans, Andy Graf, Carsten J. Beller, Lee Waite, Siegfried Hagl

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Quantitative description of left ventricular diastolic filling and mitral valve function remains difficult despite advances in echocardiography. The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement. Methods: Six animals were instrumented with aortic flow meter, left atrial pressure catheter and combined left ventricular pressure-conductance catheter. The model simulates ventricular and arterial pressures and flows during diastolic filling. Input parameters include maximum mitral valve area, blood viscosity and density, atrial compliance, left ventricular active relaxation characteristics and initial pressure and flow values. The outputs of the model are atrial and ventricular pressure as well as transmitral flow as a function of time. The model primarily consists of a system of four first-order, non-linear ordinary differential equations which were solved with MATLAB software. Results: Left atrial and ventricular pressure data and model flow curves were nearly identical under baseline conditions, during rapid preload reduction by vena caval occlusion and after prosthetic valve replacement. Measured and model based calculation of early diastolic filling volume (E-wave), showed an excellent correlation under all three conditions (r=0.998, P

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalEuropean Journal of Cardio-thoracic Surgery
Volume26
Issue number2
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Ventricular Pressure
Mitral Valve
Computer Simulation
Atrial Pressure
Hemodynamics
Catheters
Venae Cavae
Blood Viscosity
Compliance
Echocardiography
Arterial Pressure
Swine
Software
Pressure

Keywords

  • Computer model
  • Flow
  • Mitral valve
  • Pressure
  • Valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

A new computer model of mitral valve hemodynamics during ventricular filling. / Szabó, Gábor; Soans, Davis; Graf, Andy; J. Beller, Carsten; Waite, Lee; Hagl, Siegfried.

In: European Journal of Cardio-thoracic Surgery, Vol. 26, No. 2, 08.2004, p. 239-247.

Research output: Contribution to journalArticle

Szabó, Gábor ; Soans, Davis ; Graf, Andy ; J. Beller, Carsten ; Waite, Lee ; Hagl, Siegfried. / A new computer model of mitral valve hemodynamics during ventricular filling. In: European Journal of Cardio-thoracic Surgery. 2004 ; Vol. 26, No. 2. pp. 239-247.
@article{e20ffc38f935471eb0e177b73210d4d7,
title = "A new computer model of mitral valve hemodynamics during ventricular filling",
abstract = "Objective: Quantitative description of left ventricular diastolic filling and mitral valve function remains difficult despite advances in echocardiography. The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement. Methods: Six animals were instrumented with aortic flow meter, left atrial pressure catheter and combined left ventricular pressure-conductance catheter. The model simulates ventricular and arterial pressures and flows during diastolic filling. Input parameters include maximum mitral valve area, blood viscosity and density, atrial compliance, left ventricular active relaxation characteristics and initial pressure and flow values. The outputs of the model are atrial and ventricular pressure as well as transmitral flow as a function of time. The model primarily consists of a system of four first-order, non-linear ordinary differential equations which were solved with MATLAB software. Results: Left atrial and ventricular pressure data and model flow curves were nearly identical under baseline conditions, during rapid preload reduction by vena caval occlusion and after prosthetic valve replacement. Measured and model based calculation of early diastolic filling volume (E-wave), showed an excellent correlation under all three conditions (r=0.998, P",
keywords = "Computer model, Flow, Mitral valve, Pressure, Valve replacement",
author = "G{\'a}bor Szab{\'o} and Davis Soans and Andy Graf and {J. Beller}, Carsten and Lee Waite and Siegfried Hagl",
year = "2004",
month = "8",
doi = "10.1016/j.ejcts.2004.03.018",
language = "English",
volume = "26",
pages = "239--247",
journal = "European Journal of Cardio-thoracic Surgery",
issn = "1010-7940",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A new computer model of mitral valve hemodynamics during ventricular filling

AU - Szabó, Gábor

AU - Soans, Davis

AU - Graf, Andy

AU - J. Beller, Carsten

AU - Waite, Lee

AU - Hagl, Siegfried

PY - 2004/8

Y1 - 2004/8

N2 - Objective: Quantitative description of left ventricular diastolic filling and mitral valve function remains difficult despite advances in echocardiography. The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement. Methods: Six animals were instrumented with aortic flow meter, left atrial pressure catheter and combined left ventricular pressure-conductance catheter. The model simulates ventricular and arterial pressures and flows during diastolic filling. Input parameters include maximum mitral valve area, blood viscosity and density, atrial compliance, left ventricular active relaxation characteristics and initial pressure and flow values. The outputs of the model are atrial and ventricular pressure as well as transmitral flow as a function of time. The model primarily consists of a system of four first-order, non-linear ordinary differential equations which were solved with MATLAB software. Results: Left atrial and ventricular pressure data and model flow curves were nearly identical under baseline conditions, during rapid preload reduction by vena caval occlusion and after prosthetic valve replacement. Measured and model based calculation of early diastolic filling volume (E-wave), showed an excellent correlation under all three conditions (r=0.998, P

AB - Objective: Quantitative description of left ventricular diastolic filling and mitral valve function remains difficult despite advances in echocardiography. The purpose of the present study was to develop a lumped parameter model of left ventricular filling and validate it in porcine trials under physiological conditions and after valve replacement. Methods: Six animals were instrumented with aortic flow meter, left atrial pressure catheter and combined left ventricular pressure-conductance catheter. The model simulates ventricular and arterial pressures and flows during diastolic filling. Input parameters include maximum mitral valve area, blood viscosity and density, atrial compliance, left ventricular active relaxation characteristics and initial pressure and flow values. The outputs of the model are atrial and ventricular pressure as well as transmitral flow as a function of time. The model primarily consists of a system of four first-order, non-linear ordinary differential equations which were solved with MATLAB software. Results: Left atrial and ventricular pressure data and model flow curves were nearly identical under baseline conditions, during rapid preload reduction by vena caval occlusion and after prosthetic valve replacement. Measured and model based calculation of early diastolic filling volume (E-wave), showed an excellent correlation under all three conditions (r=0.998, P

KW - Computer model

KW - Flow

KW - Mitral valve

KW - Pressure

KW - Valve replacement

UR - http://www.scopus.com/inward/record.url?scp=3543081519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3543081519&partnerID=8YFLogxK

U2 - 10.1016/j.ejcts.2004.03.018

DO - 10.1016/j.ejcts.2004.03.018

M3 - Article

C2 - 15296878

AN - SCOPUS:3543081519

VL - 26

SP - 239

EP - 247

JO - European Journal of Cardio-thoracic Surgery

JF - European Journal of Cardio-thoracic Surgery

SN - 1010-7940

IS - 2

ER -