A new bifunctional GdIII complex of enhanced efficacy for MR-molecular imaging applications

Lorenzo Tei, Giuseppe Gugliotta, Zsolt Baranyai, Mauro Botta

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (kex) by nearly two orders of magnitude; the 1H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.

Original languageEnglish
Pages (from-to)9712-9714
Number of pages3
JournalDalton Transactions
Issue number44
DOIs
Publication statusPublished - Nov 16 2009

ASJC Scopus subject areas

  • Inorganic Chemistry

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