Egy új, szubsztituált benzokinon tartalmú antimetasztatikus készítmény.

Translated title of the contribution: A new benzoquinone-containing antimetastatic product

B. Szende, E. Rásó, M. Hidvégi, F. R. Tömösköziné, S. Paku, L. Prónai, J. Bocsi, K. Lapis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC. Highly significant anti-metastatic effect of MSC was observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic activity of MSC--besides the immune reconstitution--may also due to the cell-adhesion inhibitory, cell proliferation inhibitory, apoptosis-enhancing and antioxidant effects, which were also observed in our in vitro experiments. Based on the biological effects of MSC--which is non-toxic, according to subacute toxicology studies--this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immunedeprivation.

Original languageHungarian
Pages (from-to)2893-2897
Number of pages5
JournalOrvosi hetilap
Volume139
Issue number48
Publication statusPublished - Nov 29 1998

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ASJC Scopus subject areas

  • Medicine(all)

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