A new approach for development of rugged sample preparation of metabolites of albendazole in cow milk

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Abstract

Sample preparation is the critical step in analysis of residues in biological samples. The development of a rugged method is time-consuming, because a huge number of parameters must be checked. To reduce the number of experiments Taguchi's method was applied in the sample preparation of metabolites of albendazole. During the experiments 11 controllable and 7 noise factors were investigated. From the influence of controllable and noise factors on recovery and standard deviation, conditions for the sample preparation and recovery could be concluded with high accuracy and reliability.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalMikrochimica Acta
Volume130
Issue number3
Publication statusPublished - Dec 1 1999

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Keywords

  • HPLC
  • Optimisation
  • Solid phase extraction
  • Taguchi method

ASJC Scopus subject areas

  • Analytical Chemistry

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