A new and efficient one-pot synthesis of apomorphine and its ring-A halogenated derivatives

C. Csutorás, Sándor Berényi, Sándor Makleit

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rearrangement and O-demethylation of codeine (2) and various 6-demethoxythebaine derivatives 6-11 with morphinase skeletone into apomorphine (3) and its halogenated derivatives 20-24 could be efficiently executed in a one-pot operation, by treatment with methanesulfonic acid/methionine.

Original languageEnglish
Pages (from-to)2251-2256
Number of pages6
JournalSynthetic Communications
Volume26
Issue number12
Publication statusPublished - 1996

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Apomorphine
Derivatives
Codeine
Methionine
oripavine
methanesulfonic acid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A new and efficient one-pot synthesis of apomorphine and its ring-A halogenated derivatives. / Csutorás, C.; Berényi, Sándor; Makleit, Sándor.

In: Synthetic Communications, Vol. 26, No. 12, 1996, p. 2251-2256.

Research output: Contribution to journalArticle

Csutorás, C. ; Berényi, Sándor ; Makleit, Sándor. / A new and efficient one-pot synthesis of apomorphine and its ring-A halogenated derivatives. In: Synthetic Communications. 1996 ; Vol. 26, No. 12. pp. 2251-2256.
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