A new access route to functionalized cispentacins from norbornene β-amino acids

L. Kiss, Maria Cherepanova, E. Forró, F. Fülöp

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

An efficient and simple new stereocontrolled access route to novel disubstituted cispentacin derivatives with multiple stereogenic centers from norbornene β-lactam has been developed. The synthesis involves olefinic bond functionalization by dihydroxylation followed by oxidative ring cleavage and transformation of the dialdehyde intermediate through a Wittig reaction.

Original languageEnglish
Pages (from-to)2102-2107
Number of pages6
JournalChemistry - A European Journal
Volume19
Issue number6
DOIs
Publication statusPublished - Feb 4 2013

Fingerprint

Lactams
Amino acids
Derivatives
Amino Acids
2-norbornene
cispentacin

Keywords

  • cyclopentanes
  • enzymatic resolution
  • oxidation
  • stereochemistry
  • Wittig reactions

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A new access route to functionalized cispentacins from norbornene β-amino acids. / Kiss, L.; Cherepanova, Maria; Forró, E.; Fülöp, F.

In: Chemistry - A European Journal, Vol. 19, No. 6, 04.02.2013, p. 2102-2107.

Research output: Contribution to journalArticle

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