A neuroanatomical and neuroendocrinological study into the relationship between social status and the GnRH system in cooperatively breeding female Damaraland mole-rats, Cryptomys damarensis

A. J. Molteno, I. Kalló, N. C. Bennett, J. A. King, C. W. Coen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The gonadotrophin-releasing hormone (GnRH) system in female Damaraland mole-rats, Cryptomys damarensis, has been investigated to map the distribution of GnRH-immunoreactive (GnRH-IR) structures in the brain of this species and to assess whether changes in this system may mediate the inhibitory effect of social cues on fertility. The distribution of GnRH-IR cell bodies and fibres was similar to that of other mammals, forming a loose continuum along a septo-preoptico-infundibular pathway. GnRH-IR cell bodies were more abundant in the vicinity of the organum vasculosum of the lamina terminalis than in the medial basal hypothalamus. GnRH-IR cells and fibres were also found in the subfornical organ. The cell bodies were typically unipolar or bipolar. No differences were found in the morphology or size of the cell bodies or in the number of cells between non-reproductive females and reproductive females living together in a colony. However, GnRH concentrations, measured in the brain by radioimmunoassay, were significantly higher in non-reproductive females than in reproductive females; this finding was complemented by the reduced immunoreactivity for GnRH in the median eminence and proximal pituitary stalk of reproductive females. In contrast, the concentrations of GnRH measured by radioimmunoassay in non-reproductive and reproductive males did not differ. These results are consistent with the hypothesis that GnRH release is inhibited in the non-reproductive females but not in the non-reproductive males of this species.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalReproduction
Volume127
Issue number1
Publication statusPublished - Jan 2004

Fingerprint

Mole Rats
Gonadotropin-Releasing Hormone
Breeding
Radioimmunoassay
Subfornical Organ
Middle Hypothalamus
Median Eminence
Brain
Pituitary Gland
Cues
Fertility
Mammals
Cell Count

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Cell Biology
  • Endocrinology
  • Embryology

Cite this

A neuroanatomical and neuroendocrinological study into the relationship between social status and the GnRH system in cooperatively breeding female Damaraland mole-rats, Cryptomys damarensis. / Molteno, A. J.; Kalló, I.; Bennett, N. C.; King, J. A.; Coen, C. W.

In: Reproduction, Vol. 127, No. 1, 01.2004, p. 13-21.

Research output: Contribution to journalArticle

@article{9c6f3a98901b4958afe0bb77d8113fa9,
title = "A neuroanatomical and neuroendocrinological study into the relationship between social status and the GnRH system in cooperatively breeding female Damaraland mole-rats, Cryptomys damarensis",
abstract = "The gonadotrophin-releasing hormone (GnRH) system in female Damaraland mole-rats, Cryptomys damarensis, has been investigated to map the distribution of GnRH-immunoreactive (GnRH-IR) structures in the brain of this species and to assess whether changes in this system may mediate the inhibitory effect of social cues on fertility. The distribution of GnRH-IR cell bodies and fibres was similar to that of other mammals, forming a loose continuum along a septo-preoptico-infundibular pathway. GnRH-IR cell bodies were more abundant in the vicinity of the organum vasculosum of the lamina terminalis than in the medial basal hypothalamus. GnRH-IR cells and fibres were also found in the subfornical organ. The cell bodies were typically unipolar or bipolar. No differences were found in the morphology or size of the cell bodies or in the number of cells between non-reproductive females and reproductive females living together in a colony. However, GnRH concentrations, measured in the brain by radioimmunoassay, were significantly higher in non-reproductive females than in reproductive females; this finding was complemented by the reduced immunoreactivity for GnRH in the median eminence and proximal pituitary stalk of reproductive females. In contrast, the concentrations of GnRH measured by radioimmunoassay in non-reproductive and reproductive males did not differ. These results are consistent with the hypothesis that GnRH release is inhibited in the non-reproductive females but not in the non-reproductive males of this species.",
author = "Molteno, {A. J.} and I. Kall{\'o} and Bennett, {N. C.} and King, {J. A.} and Coen, {C. W.}",
year = "2004",
month = "1",
language = "English",
volume = "127",
pages = "13--21",
journal = "Reproduction",
issn = "1470-1626",
publisher = "BioScientifica Ltd.",
number = "1",

}

TY - JOUR

T1 - A neuroanatomical and neuroendocrinological study into the relationship between social status and the GnRH system in cooperatively breeding female Damaraland mole-rats, Cryptomys damarensis

AU - Molteno, A. J.

AU - Kalló, I.

AU - Bennett, N. C.

AU - King, J. A.

AU - Coen, C. W.

PY - 2004/1

Y1 - 2004/1

N2 - The gonadotrophin-releasing hormone (GnRH) system in female Damaraland mole-rats, Cryptomys damarensis, has been investigated to map the distribution of GnRH-immunoreactive (GnRH-IR) structures in the brain of this species and to assess whether changes in this system may mediate the inhibitory effect of social cues on fertility. The distribution of GnRH-IR cell bodies and fibres was similar to that of other mammals, forming a loose continuum along a septo-preoptico-infundibular pathway. GnRH-IR cell bodies were more abundant in the vicinity of the organum vasculosum of the lamina terminalis than in the medial basal hypothalamus. GnRH-IR cells and fibres were also found in the subfornical organ. The cell bodies were typically unipolar or bipolar. No differences were found in the morphology or size of the cell bodies or in the number of cells between non-reproductive females and reproductive females living together in a colony. However, GnRH concentrations, measured in the brain by radioimmunoassay, were significantly higher in non-reproductive females than in reproductive females; this finding was complemented by the reduced immunoreactivity for GnRH in the median eminence and proximal pituitary stalk of reproductive females. In contrast, the concentrations of GnRH measured by radioimmunoassay in non-reproductive and reproductive males did not differ. These results are consistent with the hypothesis that GnRH release is inhibited in the non-reproductive females but not in the non-reproductive males of this species.

AB - The gonadotrophin-releasing hormone (GnRH) system in female Damaraland mole-rats, Cryptomys damarensis, has been investigated to map the distribution of GnRH-immunoreactive (GnRH-IR) structures in the brain of this species and to assess whether changes in this system may mediate the inhibitory effect of social cues on fertility. The distribution of GnRH-IR cell bodies and fibres was similar to that of other mammals, forming a loose continuum along a septo-preoptico-infundibular pathway. GnRH-IR cell bodies were more abundant in the vicinity of the organum vasculosum of the lamina terminalis than in the medial basal hypothalamus. GnRH-IR cells and fibres were also found in the subfornical organ. The cell bodies were typically unipolar or bipolar. No differences were found in the morphology or size of the cell bodies or in the number of cells between non-reproductive females and reproductive females living together in a colony. However, GnRH concentrations, measured in the brain by radioimmunoassay, were significantly higher in non-reproductive females than in reproductive females; this finding was complemented by the reduced immunoreactivity for GnRH in the median eminence and proximal pituitary stalk of reproductive females. In contrast, the concentrations of GnRH measured by radioimmunoassay in non-reproductive and reproductive males did not differ. These results are consistent with the hypothesis that GnRH release is inhibited in the non-reproductive females but not in the non-reproductive males of this species.

UR - http://www.scopus.com/inward/record.url?scp=1242273621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242273621&partnerID=8YFLogxK

M3 - Article

C2 - 15056766

AN - SCOPUS:1242273621

VL - 127

SP - 13

EP - 21

JO - Reproduction

JF - Reproduction

SN - 1470-1626

IS - 1

ER -