A natural IgM antibody does inhibit polyclonal and antigen-specific IgM but not IgG B-cell responses

Katalin Kiss, F. Uher, J. Gergely

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Since a B-cell growth-inhibitory natural IgM antibody was identified in the culture supernatants of LPS-stimulated murine splenic B lymphocytes [11], attempts have been made to define other possible functional role(s) of this antibody. Here we show that this regulatory IgM is able to inhibit not only the proliferation of splenic B cells, but also their IgM secretion during LPS-induced polyclonal, as well as antigen (FITC-KLH)-specific antibody responses. In contrast, IgG1 production of hapten (FITC)-specific B cells neither during restimulation with LPS nor in the presence of carrier-specific T lymphocytes in vitro was affected by regulatory IgM. Therefore, whereas newly emerging naive B cells are highly susceptible, IgG-secreting B cells appear to be completely resistant to inactivation by the regulatory IgM autoantibody.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalImmunology Letters
Volume39
Issue number3
DOIs
Publication statusPublished - 1994

Fingerprint

Immunoglobulin M
B-Lymphocytes
Immunoglobulin G
Antigens
Antibodies
Haptens
Fluorescein-5-isothiocyanate
Autoantibodies
Antibody Formation
T-Lymphocytes
Growth

Keywords

  • (Mouse)
  • B cell
  • Memory response
  • Natural IgM

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

A natural IgM antibody does inhibit polyclonal and antigen-specific IgM but not IgG B-cell responses. / Kiss, Katalin; Uher, F.; Gergely, J.

In: Immunology Letters, Vol. 39, No. 3, 1994, p. 235-241.

Research output: Contribution to journalArticle

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