A multidimensional threshold model for multiple congenital abnormalities.

E. Czeizel, L. Telegdi, G. Tusnády

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Abstract

Analysis of the data of 2.762 infants with "unidentified" (i.e., no identified as dysmorphological entities) multiple congenital abnormalities from the Hungarian Congenital Malformation Registry, 1970-1976 showed that the majority of congenital abnormalities in newborns with multiple congenital abnormalities was not due to random combinations. The ratio of expected random combination and observed causal effect was 1: 6, 1: 225-1: 14,000 and 1: 2.10(6) in two, three, four, and five or more congenital abnormalities, respectively. Our multidimensional threshold model supposes specified liabilities for each congenital abnormality, and the correlation structure of these liabilities explains nearly all associations of congenital abnormalities in unidentified multiple congenital abnormalities. According to this hypothesis, the expected and the observed occurrences do not differ significantly either in the sum or in the various possible threefold associations of congenital abnormalities. The biological reasons for the phenomenon are being studied.

Original languageEnglish
Pages (from-to)189-204
Number of pages16
JournalActa Paediatrica Hungarica
Volume27
Issue number3
Publication statusPublished - 1986

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Multiple Abnormalities
Biological Phenomena
Registries
Newborn Infant

ASJC Scopus subject areas

  • Medicine(all)

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A multidimensional threshold model for multiple congenital abnormalities. / Czeizel, E.; Telegdi, L.; Tusnády, G.

In: Acta Paediatrica Hungarica, Vol. 27, No. 3, 1986, p. 189-204.

Research output: Contribution to journalArticle

Czeizel, E. ; Telegdi, L. ; Tusnády, G. / A multidimensional threshold model for multiple congenital abnormalities. In: Acta Paediatrica Hungarica. 1986 ; Vol. 27, No. 3. pp. 189-204.
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