A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Nathaniel Rothman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Nuria Malats, Xifeng Wu, Jonine D. Figueroa, Francisco X. Real, David Van Den Berg, Giuseppe Matullo, Dalsu Baris, Michael Thun, Lambertus A. Kiemeney, Paolo Vineis, Immaculata De Vivo, Demetrius Albanes, Mark P. Purdue, Thorunn Rafnar, Michelle A T Hildebrandt, Anne E. Kiltie, Olivier CussenotKlaus Golka, Rajiv Kumar, Jack A. Taylor, Jose I. Mayordomo, Kevin B. Jacobs, Manolis Kogevinas, Amy Hutchinson, Zhaoming Wang, Yi Ping Fu, Ludmila Prokunina-Oolsson, Laurie BurdeT, Meredith Yeager, William Wheeler, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Cclosas, Josep Loreta, Alison Johnson, Molly Schwenn, Margaret R. Karagas, Alan Schned, Gerald Andriole, Robert Grubb, Amanda Black, Eric J. Jacobs, W. Ryan Diver, Susan M. Gapstur, Stephanie J. Weinstein, Jarmo Virtamo, Victoria K. Cortessis, Manuela Gago-Dominguez, Malcolm C. Pike, Mariana C. Stern, Jian Min Yuan, David J. Hunter, Monica McGgrath, Colin P. Dinney, Bogdan Czerniak, Meng Chen, Hushan Yang, Sita H. Vermeulen, Katja K. Aben, J. Alfred Witjes, Remco R. MaKinje, Patrick Sulem, Soren Besenbacher, Kari Stefansson, Elio Riboli, Paul Brennan, Salvatore Panico, Carmen Navarro, Naomi E. Allen, H. Bas Bueno-De-Mesquita, Dimitrios Trichopoulos, Neil Caporaso, Maria Teresa Landi, Federico Canzian, Borje Ljungberg, Anne Tjonneland, Francoise Clavel-Chapelon, David T. Bishop, Mark T W Teo, Margaret A. Knowles, Simonetta Guarrera, Silvia Polidoro, Fulvio Ricceri, Carlotta Sacerdote, Alessandra Allione, Geraldine Cancel-Tassin, Silvia Selinski, Jan G. Hengstler, Holger Dietrich, Tony Fletcher, P. Rudnai, Eugen Gurzau, Kvetoslava Koppova, Sophia C E Bolick, Ashley Godfrey, Zongli Xu, José I. Sanz-Velez, María D García Prats, Manuel Sanchez, Gabriel Valdivia, Stefano Porru, Simone Benhamou, Robert N. Hoover, Joseph F. Fraumeni, Debra T. Silverman, Stephen J. Chanock

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.

Original languageEnglish
Pages (from-to)978-984
Number of pages7
JournalNature Genetics
Volume42
Issue number11
DOIs
Publication statusPublished - Nov 1 2010

Fingerprint

Genome-Wide Association Study
Urinary Bladder Neoplasms
Chromosomes
Single Nucleotide Polymorphism
Genome
Neoplasms
Acetylation
Carcinogenesis
Smoking

ASJC Scopus subject areas

  • Genetics

Cite this

Rothman, N., Garcia-Closas, M., Chatterjee, N., Malats, N., Wu, X., Figueroa, J. D., ... Chanock, S. J. (2010). A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nature Genetics, 42(11), 978-984. https://doi.org/10.1038/ng.687

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. / Rothman, Nathaniel; Garcia-Closas, Montserrat; Chatterjee, Nilanjan; Malats, Nuria; Wu, Xifeng; Figueroa, Jonine D.; Real, Francisco X.; Van Den Berg, David; Matullo, Giuseppe; Baris, Dalsu; Thun, Michael; Kiemeney, Lambertus A.; Vineis, Paolo; De Vivo, Immaculata; Albanes, Demetrius; Purdue, Mark P.; Rafnar, Thorunn; Hildebrandt, Michelle A T; Kiltie, Anne E.; Cussenot, Olivier; Golka, Klaus; Kumar, Rajiv; Taylor, Jack A.; Mayordomo, Jose I.; Jacobs, Kevin B.; Kogevinas, Manolis; Hutchinson, Amy; Wang, Zhaoming; Fu, Yi Ping; Prokunina-Oolsson, Ludmila; BurdeT, Laurie; Yeager, Meredith; Wheeler, William; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; García-Cclosas, Reina; Loreta, Josep; Johnson, Alison; Schwenn, Molly; Karagas, Margaret R.; Schned, Alan; Andriole, Gerald; Grubb, Robert; Black, Amanda; Jacobs, Eric J.; Diver, W. Ryan; Gapstur, Susan M.; Weinstein, Stephanie J.; Virtamo, Jarmo; Cortessis, Victoria K.; Gago-Dominguez, Manuela; Pike, Malcolm C.; Stern, Mariana C.; Yuan, Jian Min; Hunter, David J.; McGgrath, Monica; Dinney, Colin P.; Czerniak, Bogdan; Chen, Meng; Yang, Hushan; Vermeulen, Sita H.; Aben, Katja K.; Witjes, J. Alfred; MaKinje, Remco R.; Sulem, Patrick; Besenbacher, Soren; Stefansson, Kari; Riboli, Elio; Brennan, Paul; Panico, Salvatore; Navarro, Carmen; Allen, Naomi E.; Bueno-De-Mesquita, H. Bas; Trichopoulos, Dimitrios; Caporaso, Neil; Landi, Maria Teresa; Canzian, Federico; Ljungberg, Borje; Tjonneland, Anne; Clavel-Chapelon, Francoise; Bishop, David T.; Teo, Mark T W; Knowles, Margaret A.; Guarrera, Simonetta; Polidoro, Silvia; Ricceri, Fulvio; Sacerdote, Carlotta; Allione, Alessandra; Cancel-Tassin, Geraldine; Selinski, Silvia; Hengstler, Jan G.; Dietrich, Holger; Fletcher, Tony; Rudnai, P.; Gurzau, Eugen; Koppova, Kvetoslava; Bolick, Sophia C E; Godfrey, Ashley; Xu, Zongli; Sanz-Velez, José I.; Prats, María D García; Sanchez, Manuel; Valdivia, Gabriel; Porru, Stefano; Benhamou, Simone; Hoover, Robert N.; Fraumeni, Joseph F.; Silverman, Debra T.; Chanock, Stephen J.

In: Nature Genetics, Vol. 42, No. 11, 01.11.2010, p. 978-984.

Research output: Contribution to journalArticle

Rothman, N, Garcia-Closas, M, Chatterjee, N, Malats, N, Wu, X, Figueroa, JD, Real, FX, Van Den Berg, D, Matullo, G, Baris, D, Thun, M, Kiemeney, LA, Vineis, P, De Vivo, I, Albanes, D, Purdue, MP, Rafnar, T, Hildebrandt, MAT, Kiltie, AE, Cussenot, O, Golka, K, Kumar, R, Taylor, JA, Mayordomo, JI, Jacobs, KB, Kogevinas, M, Hutchinson, A, Wang, Z, Fu, YP, Prokunina-Oolsson, L, BurdeT, L, Yeager, M, Wheeler, W, Tardón, A, Serra, C, Carrato, A, García-Cclosas, R, Loreta, J, Johnson, A, Schwenn, M, Karagas, MR, Schned, A, Andriole, G, Grubb, R, Black, A, Jacobs, EJ, Diver, WR, Gapstur, SM, Weinstein, SJ, Virtamo, J, Cortessis, VK, Gago-Dominguez, M, Pike, MC, Stern, MC, Yuan, JM, Hunter, DJ, McGgrath, M, Dinney, CP, Czerniak, B, Chen, M, Yang, H, Vermeulen, SH, Aben, KK, Witjes, JA, MaKinje, RR, Sulem, P, Besenbacher, S, Stefansson, K, Riboli, E, Brennan, P, Panico, S, Navarro, C, Allen, NE, Bueno-De-Mesquita, HB, Trichopoulos, D, Caporaso, N, Landi, MT, Canzian, F, Ljungberg, B, Tjonneland, A, Clavel-Chapelon, F, Bishop, DT, Teo, MTW, Knowles, MA, Guarrera, S, Polidoro, S, Ricceri, F, Sacerdote, C, Allione, A, Cancel-Tassin, G, Selinski, S, Hengstler, JG, Dietrich, H, Fletcher, T, Rudnai, P, Gurzau, E, Koppova, K, Bolick, SCE, Godfrey, A, Xu, Z, Sanz-Velez, JI, Prats, MDG, Sanchez, M, Valdivia, G, Porru, S, Benhamou, S, Hoover, RN, Fraumeni, JF, Silverman, DT & Chanock, SJ 2010, 'A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci', Nature Genetics, vol. 42, no. 11, pp. 978-984. https://doi.org/10.1038/ng.687
Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nature Genetics. 2010 Nov 1;42(11):978-984. https://doi.org/10.1038/ng.687
Rothman, Nathaniel ; Garcia-Closas, Montserrat ; Chatterjee, Nilanjan ; Malats, Nuria ; Wu, Xifeng ; Figueroa, Jonine D. ; Real, Francisco X. ; Van Den Berg, David ; Matullo, Giuseppe ; Baris, Dalsu ; Thun, Michael ; Kiemeney, Lambertus A. ; Vineis, Paolo ; De Vivo, Immaculata ; Albanes, Demetrius ; Purdue, Mark P. ; Rafnar, Thorunn ; Hildebrandt, Michelle A T ; Kiltie, Anne E. ; Cussenot, Olivier ; Golka, Klaus ; Kumar, Rajiv ; Taylor, Jack A. ; Mayordomo, Jose I. ; Jacobs, Kevin B. ; Kogevinas, Manolis ; Hutchinson, Amy ; Wang, Zhaoming ; Fu, Yi Ping ; Prokunina-Oolsson, Ludmila ; BurdeT, Laurie ; Yeager, Meredith ; Wheeler, William ; Tardón, Adonina ; Serra, Consol ; Carrato, Alfredo ; García-Cclosas, Reina ; Loreta, Josep ; Johnson, Alison ; Schwenn, Molly ; Karagas, Margaret R. ; Schned, Alan ; Andriole, Gerald ; Grubb, Robert ; Black, Amanda ; Jacobs, Eric J. ; Diver, W. Ryan ; Gapstur, Susan M. ; Weinstein, Stephanie J. ; Virtamo, Jarmo ; Cortessis, Victoria K. ; Gago-Dominguez, Manuela ; Pike, Malcolm C. ; Stern, Mariana C. ; Yuan, Jian Min ; Hunter, David J. ; McGgrath, Monica ; Dinney, Colin P. ; Czerniak, Bogdan ; Chen, Meng ; Yang, Hushan ; Vermeulen, Sita H. ; Aben, Katja K. ; Witjes, J. Alfred ; MaKinje, Remco R. ; Sulem, Patrick ; Besenbacher, Soren ; Stefansson, Kari ; Riboli, Elio ; Brennan, Paul ; Panico, Salvatore ; Navarro, Carmen ; Allen, Naomi E. ; Bueno-De-Mesquita, H. Bas ; Trichopoulos, Dimitrios ; Caporaso, Neil ; Landi, Maria Teresa ; Canzian, Federico ; Ljungberg, Borje ; Tjonneland, Anne ; Clavel-Chapelon, Francoise ; Bishop, David T. ; Teo, Mark T W ; Knowles, Margaret A. ; Guarrera, Simonetta ; Polidoro, Silvia ; Ricceri, Fulvio ; Sacerdote, Carlotta ; Allione, Alessandra ; Cancel-Tassin, Geraldine ; Selinski, Silvia ; Hengstler, Jan G. ; Dietrich, Holger ; Fletcher, Tony ; Rudnai, P. ; Gurzau, Eugen ; Koppova, Kvetoslava ; Bolick, Sophia C E ; Godfrey, Ashley ; Xu, Zongli ; Sanz-Velez, José I. ; Prats, María D García ; Sanchez, Manuel ; Valdivia, Gabriel ; Porru, Stefano ; Benhamou, Simone ; Hoover, Robert N. ; Fraumeni, Joseph F. ; Silverman, Debra T. ; Chanock, Stephen J. / A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. In: Nature Genetics. 2010 ; Vol. 42, No. 11. pp. 978-984.
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abstract = "We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.",
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T1 - A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

AU - Rothman, Nathaniel

AU - Garcia-Closas, Montserrat

AU - Chatterjee, Nilanjan

AU - Malats, Nuria

AU - Wu, Xifeng

AU - Figueroa, Jonine D.

AU - Real, Francisco X.

AU - Van Den Berg, David

AU - Matullo, Giuseppe

AU - Baris, Dalsu

AU - Thun, Michael

AU - Kiemeney, Lambertus A.

AU - Vineis, Paolo

AU - De Vivo, Immaculata

AU - Albanes, Demetrius

AU - Purdue, Mark P.

AU - Rafnar, Thorunn

AU - Hildebrandt, Michelle A T

AU - Kiltie, Anne E.

AU - Cussenot, Olivier

AU - Golka, Klaus

AU - Kumar, Rajiv

AU - Taylor, Jack A.

AU - Mayordomo, Jose I.

AU - Jacobs, Kevin B.

AU - Kogevinas, Manolis

AU - Hutchinson, Amy

AU - Wang, Zhaoming

AU - Fu, Yi Ping

AU - Prokunina-Oolsson, Ludmila

AU - BurdeT, Laurie

AU - Yeager, Meredith

AU - Wheeler, William

AU - Tardón, Adonina

AU - Serra, Consol

AU - Carrato, Alfredo

AU - García-Cclosas, Reina

AU - Loreta, Josep

AU - Johnson, Alison

AU - Schwenn, Molly

AU - Karagas, Margaret R.

AU - Schned, Alan

AU - Andriole, Gerald

AU - Grubb, Robert

AU - Black, Amanda

AU - Jacobs, Eric J.

AU - Diver, W. Ryan

AU - Gapstur, Susan M.

AU - Weinstein, Stephanie J.

AU - Virtamo, Jarmo

AU - Cortessis, Victoria K.

AU - Gago-Dominguez, Manuela

AU - Pike, Malcolm C.

AU - Stern, Mariana C.

AU - Yuan, Jian Min

AU - Hunter, David J.

AU - McGgrath, Monica

AU - Dinney, Colin P.

AU - Czerniak, Bogdan

AU - Chen, Meng

AU - Yang, Hushan

AU - Vermeulen, Sita H.

AU - Aben, Katja K.

AU - Witjes, J. Alfred

AU - MaKinje, Remco R.

AU - Sulem, Patrick

AU - Besenbacher, Soren

AU - Stefansson, Kari

AU - Riboli, Elio

AU - Brennan, Paul

AU - Panico, Salvatore

AU - Navarro, Carmen

AU - Allen, Naomi E.

AU - Bueno-De-Mesquita, H. Bas

AU - Trichopoulos, Dimitrios

AU - Caporaso, Neil

AU - Landi, Maria Teresa

AU - Canzian, Federico

AU - Ljungberg, Borje

AU - Tjonneland, Anne

AU - Clavel-Chapelon, Francoise

AU - Bishop, David T.

AU - Teo, Mark T W

AU - Knowles, Margaret A.

AU - Guarrera, Simonetta

AU - Polidoro, Silvia

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Allione, Alessandra

AU - Cancel-Tassin, Geraldine

AU - Selinski, Silvia

AU - Hengstler, Jan G.

AU - Dietrich, Holger

AU - Fletcher, Tony

AU - Rudnai, P.

AU - Gurzau, Eugen

AU - Koppova, Kvetoslava

AU - Bolick, Sophia C E

AU - Godfrey, Ashley

AU - Xu, Zongli

AU - Sanz-Velez, José I.

AU - Prats, María D García

AU - Sanchez, Manuel

AU - Valdivia, Gabriel

AU - Porru, Stefano

AU - Benhamou, Simone

AU - Hoover, Robert N.

AU - Fraumeni, Joseph F.

AU - Silverman, Debra T.

AU - Chanock, Stephen J.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.

AB - We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.

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