A modification of the Pr value equation for measuring the compactibility of pharmaceutical materials

I. Ilić, P. Kása, R. Dreu, K. Pintye-Hódi, S. Srčič

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Various types of lactose were used to study compactibility using Pr [11]. The dependence of Pr on the compression pressure, used to produce tablets, makes its comparison very difficult and so this phenomenon was studied in detail. It was demonstrated that Pr in its original form is the quotient of two linear functions and has a mathematical dependence on compression force. Therefore, a modification of this equation is proposed (termed Pr') that increases its practical usefulness. The equation for pressure-independent Pr' allows for comparison of various materials and/or studies in which different compression pressure values are used, even at low pressures where comparison of Pr itself is not feasible.

Original languageEnglish
Pages (from-to)881-884
Number of pages4
JournalChemical Engineering and Processing: Process Intensification
Volume49
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Drug products
Pharmaceutical Preparations
Lactose
Tablets
Compaction

Keywords

  • Compactibility
  • Lactose
  • Pr
  • Specific work
  • Tensile strength

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)
  • Industrial and Manufacturing Engineering
  • Energy Engineering and Power Technology

Cite this

A modification of the Pr value equation for measuring the compactibility of pharmaceutical materials. / Ilić, I.; Kása, P.; Dreu, R.; Pintye-Hódi, K.; Srčič, S.

In: Chemical Engineering and Processing: Process Intensification, Vol. 49, No. 8, 08.2010, p. 881-884.

Research output: Contribution to journalArticle

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