A meta-analysis of the Val158Met COMT polymorphism and violent behavior in Schizophrenia

Jay P. Singh, Jan Volavka, P. Czobor, Richard A. van Dorn

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We conducted a meta-analysis of studies examining the association between the Val158Met COMT polymorphism and violence against others in schizophrenia. A systematic search current to November 1, 2011 was conducted using MEDLINE, EMBASE, CINAHL, PsycINFO, ProQuest, and the National Criminal Justice Reference Service and identified 15 studies comprising 2,370 individuals with schizophrenia for inclusion. Bivariate analyses of study sensitivities and specificities were conducted. This methodology allowed for the calculation of pooled diagnostic odds ratios (DOR). Evidence of a significant association between the presence of a Met allele and violence was found such that men's violence risk increased by approximately 50% for those with at least one Met allele compared with homozygous Val individuals (DOR = 1.45; 95% CI = 1.05-2.00; z = 2.37, p = 0.02). No significant association between the presence of a Met allele and violence was found for women or when outcome was restricted to homicide. We conclude that male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence. This finding has potential implications for the pharmacogenetics of violent behavior in schizophrenia.

Original languageEnglish
Article numbere43423
JournalPLoS One
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 14 2012

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violence
Polymorphism
meta-analysis
Violence
Meta-Analysis
Schizophrenia
genetic polymorphism
Alleles
alleles
odds ratio
Odds Ratio
pharmacogenomics
Criminal Law
Homicide
Pharmacogenetics
MEDLINE
Genes
schizophrenia
Sensitivity and Specificity
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A meta-analysis of the Val158Met COMT polymorphism and violent behavior in Schizophrenia. / Singh, Jay P.; Volavka, Jan; Czobor, P.; van Dorn, Richard A.

In: PLoS One, Vol. 7, No. 8, e43423, 14.08.2012.

Research output: Contribution to journalArticle

Singh, Jay P. ; Volavka, Jan ; Czobor, P. ; van Dorn, Richard A. / A meta-analysis of the Val158Met COMT polymorphism and violent behavior in Schizophrenia. In: PLoS One. 2012 ; Vol. 7, No. 8.
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