A mammalian in vitro model to study gangliogenesis from neural crest cells

S. Boisseau, V. Poirier, O. Semonin, L. Leconte, M. Santha, C. Poujeol, G. Rougon, M. Simonneau

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In spite of considerable advances towards understanding lineages derived from neural crest cells using amphibian and avian embryos, the molecular mechanisms involved in the formation of mammalian peripheral ganglia remain largely unknown, mainly because of the lack of experimental systems that will allow their in vitro manipulation. Here, we present a novel mammalian in vitro model permitting to study gangliogenesis from neural crest cells. This model allowed us to manipulate molecules involved in cell-cell interactions. Our data are in favour of the existence of a hierarchy among adhesion molecules.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalJournal de Physiologie
Volume85
Issue number3
Publication statusPublished - Dec 1 1991

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Keywords

  • endoneuraminidase
  • high polysialic acid N-CAM
  • mouse
  • neural cell adhesion molecules
  • neural crest cells
  • peripheral nervous system

ASJC Scopus subject areas

  • Physiology

Cite this

Boisseau, S., Poirier, V., Semonin, O., Leconte, L., Santha, M., Poujeol, C., Rougon, G., & Simonneau, M. (1991). A mammalian in vitro model to study gangliogenesis from neural crest cells. Journal de Physiologie, 85(3), 117-122.