A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide

J. Peter H Burbach, G. Kovács, David De Wied, Jan W. Van Nispen, Henk M. Greven

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

A peptide that accumulated as the major product during the proteolysis of arginine vasopressin by rat brain synaptic membranes was isolated and its structure was shown to be the hexapeptide pGlu-Asn-Cys(Cys)-Pro-Arg-Gly-NH 2. When administered intracerebroventricularly in extremely low doses, this vasopressin fragment and its desglycinamide derivative facilitated memory consolidation in a passive avoidance situation. These vasopressin metabolites, which are devoid of pressor activity, constitute highly potent neuropeptides with selective effects on memory and related processes; they are activated via proteolytic processing of vasopressin by brain peptidases.

Original languageEnglish
Pages (from-to)1310-1312
Number of pages3
JournalScience
Volume221
Issue number4617
Publication statusPublished - 1983

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Arginine Vasopressin
Neuropeptides
Vasopressins
Brain
Synaptic Membranes
Proteolysis
Peptide Hydrolases
Peptides

ASJC Scopus subject areas

  • General

Cite this

Burbach, J. P. H., Kovács, G., De Wied, D., Van Nispen, J. W., & Greven, H. M. (1983). A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. Science, 221(4617), 1310-1312.

A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. / Burbach, J. Peter H; Kovács, G.; De Wied, David; Van Nispen, Jan W.; Greven, Henk M.

In: Science, Vol. 221, No. 4617, 1983, p. 1310-1312.

Research output: Contribution to journalArticle

Burbach, JPH, Kovács, G, De Wied, D, Van Nispen, JW & Greven, HM 1983, 'A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide', Science, vol. 221, no. 4617, pp. 1310-1312.
Burbach JPH, Kovács G, De Wied D, Van Nispen JW, Greven HM. A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. Science. 1983;221(4617):1310-1312.
Burbach, J. Peter H ; Kovács, G. ; De Wied, David ; Van Nispen, Jan W. ; Greven, Henk M. / A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. In: Science. 1983 ; Vol. 221, No. 4617. pp. 1310-1312.
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