Abstract
Chimerism is an exceptional immunogenetic state, characterized by the survival and collaboration of cell populations originated from two different individuals. The prerequisites to induce chimerism are immunosuppression, myeloablation or severe immunodeficiency of the recipients on one side and donor originated immuno-hematopoietic cells in the graft on the other. Special immunogenetic conditions to establish chimerism are combined with bone marrow transplantation, transfusion and various kinds of solid organ grafting. There are various methods to detect the type of chimera state depending on the immunogenetic differences between the donor and recipient. The chimera state seems to be one of the leading factors to influence the course of the post-transplant period, the frequency and severity of graft-versus-host disease (GVHD), and the rate of relapse. However, the most important contribution of the chimeric state is the development of graft versus leukemia (GVL) effect. A new conditioning protocol (DBM/Ara-C/Cy) for allogeneic BMT in CML patients and its consequence on chimera state and GVL effect is demonstrated.
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 15-21 |
| Number of pages | 7 |
| Journal | Magyar Onkologia |
| Volume | 45 |
| Issue number | 1 |
| Publication status | Published - 2001 |
ASJC Scopus subject areas
- Oncology
Cite this
A kimerizmus immunpatológiai és klinikai jelento{double acute}sége csontvelo{double acute}-transzplantációban és szervátültetésekben. / Anikó, Barta; Lilla, Lengyel; Andrea, Sipos; Éva, Torbágyi; János, Földi; Piroska, Páldi Haris; Júlia, Tamáska; Éva, Gyódi; Rajczy, K.; Izabella, Hoffer; Judit, Jakab; Luca, Kormos; Petrányi, G.; Pálóczi, K.
In: Magyar Onkologia, Vol. 45, No. 1, 2001, p. 15-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A kimerizmus immunpatológiai és klinikai jelento{double acute}sége csontvelo{double acute}-transzplantációban és szervátültetésekben
AU - Anikó, Barta
AU - Lilla, Lengyel
AU - Andrea, Sipos
AU - Éva, Torbágyi
AU - János, Földi
AU - Piroska, Páldi Haris
AU - Júlia, Tamáska
AU - Éva, Gyódi
AU - Rajczy, K.
AU - Izabella, Hoffer
AU - Judit, Jakab
AU - Luca, Kormos
AU - Petrányi, G.
AU - Pálóczi, K.
PY - 2001
Y1 - 2001
N2 - Chimerism is an exceptional immunogenetic state, characterized by the survival and collaboration of cell populations originated from two different individuals. The prerequisites to induce chimerism are immunosuppression, myeloablation or severe immunodeficiency of the recipients on one side and donor originated immuno-hematopoietic cells in the graft on the other. Special immunogenetic conditions to establish chimerism are combined with bone marrow transplantation, transfusion and various kinds of solid organ grafting. There are various methods to detect the type of chimera state depending on the immunogenetic differences between the donor and recipient. The chimera state seems to be one of the leading factors to influence the course of the post-transplant period, the frequency and severity of graft-versus-host disease (GVHD), and the rate of relapse. However, the most important contribution of the chimeric state is the development of graft versus leukemia (GVL) effect. A new conditioning protocol (DBM/Ara-C/Cy) for allogeneic BMT in CML patients and its consequence on chimera state and GVL effect is demonstrated.
AB - Chimerism is an exceptional immunogenetic state, characterized by the survival and collaboration of cell populations originated from two different individuals. The prerequisites to induce chimerism are immunosuppression, myeloablation or severe immunodeficiency of the recipients on one side and donor originated immuno-hematopoietic cells in the graft on the other. Special immunogenetic conditions to establish chimerism are combined with bone marrow transplantation, transfusion and various kinds of solid organ grafting. There are various methods to detect the type of chimera state depending on the immunogenetic differences between the donor and recipient. The chimera state seems to be one of the leading factors to influence the course of the post-transplant period, the frequency and severity of graft-versus-host disease (GVHD), and the rate of relapse. However, the most important contribution of the chimeric state is the development of graft versus leukemia (GVL) effect. A new conditioning protocol (DBM/Ara-C/Cy) for allogeneic BMT in CML patients and its consequence on chimera state and GVL effect is demonstrated.
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M3 - Article
VL - 45
SP - 15
EP - 21
JO - Magyar Onkologia
JF - Magyar Onkologia
SN - 0025-0244
IS - 1
ER -