A kemoprevenció biomarker indikátorai fémexponá ltak körében

Major Jenó, Jakab Mátyás, Biró Anna, Klupp Tibor, Magyar Balázs, Gál Katalin, Oláh Gábor, Fodor Zoltán, Tompa Anna

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Chemoprevention with chelating agent Humetta® for three months was performed, due to anaemia and other haematologic disorders, immunotoxicological alterations and/or increased chromosome aberration rate among galvanisers and goldsmiths occupationally exposed to precious and heavy metals. Twenty-two of altogether 47 subjects took part voluntarily in the chemoprevention, and the rest of the subjects served as untreated controls. Complex clinical laboratory testing including detailed anamneses; genotoxicological and immunotoxicological monitoring were performed before and after administration of chemopreventive agent. After chemoprevention a significant improvement was observed in anaemia and serum glucose levels, while a less marked improvement was found in serum cholesterol levels and liver functions. Altered chromosome aberration and apoptotic cell fraction also tended to normalise after treatment. Immunological parameters were not affected by the treatment. The obtained results may suggest that chemoprevention with chelating agents as Humetta® can help in the prevention of harmful effects of occupational exposures to metals.

Original languageHungarian
Pages (from-to)125-129
Number of pages5
JournalMagyar onkologia
Issue number2
Publication statusPublished - Dec 1 2004

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jenó, M., Mátyás, J., Anna, B., Tibor, K., Balázs, M., Katalin, G., Gábor, O., Zoltán, F., & Anna, T. (2004). A kemoprevenció biomarker indikátorai fémexponá ltak körében. Magyar onkologia, 48(2), 125-129.