A hypothalamic alpha-adrenergic mechanism mediating the thermogenic response to electrical stimulation of the lower brainstem in the guinea pig

Z. Szelényi, Eugen Zeisberger, Kurt Brück

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient temperature ESLB elicited a thermogenic response resembling that evoked by microinjection of noradrenaline into the hypothalamus. The response consisted of a rise in oxygen uptake (to more than 50% of the resting value) and of body temperatures, especially of the interscapular adipose tissue. In some cases shivering was also evoked. The thermogenic response to ESLB was completely blocked by additional microinjection of an adrenergic alpha-receptor blocker, phentolamine, into the hypothalamic area where the noradrenergic fibres were presumed to terminate. Subsequent intrahypothalamic injection of noradrenaline, which had formerly been shown to restore the decreased responses to repeated ESLB, failed to restore the effectiveness of ESLB after phentolamine. It is concluded that the thermogenic responses to ESLB are mediated by a noradrenergic pathway ascending to the hypothalamus and not by direct stimulation of efferent pathways controlling the peripheral target system. The hypothalamic transmission can be prevented by an alpha-adrenergic blockade.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalPflugers Archiv European Journal of Physiology
Volume370
Issue number1
DOIs
Publication statusPublished - Jan 1977

Fingerprint

Deep Brain Stimulation
Adrenergic Agents
Electric Stimulation
Brain Stem
Brain
Guinea Pigs
Phentolamine
Microinjections
Hypothalamus
Norepinephrine
Adrenergic alpha-Antagonists
Shivering
Efferent Pathways
Receptors, Adrenergic, alpha
Body Temperature
Adipose Tissue
Tissue
Oxygen
Temperature
Injections

Keywords

  • Adrenergic alpha-receptor blocking agents
  • Central control of thermogenesis
  • Central noradrenergic pathways
  • Electrical brainstem stimulation

ASJC Scopus subject areas

  • Physiology

Cite this

@article{f768fd72b3484932ba9b1a9a90403dad,
title = "A hypothalamic alpha-adrenergic mechanism mediating the thermogenic response to electrical stimulation of the lower brainstem in the guinea pig",
abstract = "Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient temperature ESLB elicited a thermogenic response resembling that evoked by microinjection of noradrenaline into the hypothalamus. The response consisted of a rise in oxygen uptake (to more than 50{\%} of the resting value) and of body temperatures, especially of the interscapular adipose tissue. In some cases shivering was also evoked. The thermogenic response to ESLB was completely blocked by additional microinjection of an adrenergic alpha-receptor blocker, phentolamine, into the hypothalamic area where the noradrenergic fibres were presumed to terminate. Subsequent intrahypothalamic injection of noradrenaline, which had formerly been shown to restore the decreased responses to repeated ESLB, failed to restore the effectiveness of ESLB after phentolamine. It is concluded that the thermogenic responses to ESLB are mediated by a noradrenergic pathway ascending to the hypothalamus and not by direct stimulation of efferent pathways controlling the peripheral target system. The hypothalamic transmission can be prevented by an alpha-adrenergic blockade.",
keywords = "Adrenergic alpha-receptor blocking agents, Central control of thermogenesis, Central noradrenergic pathways, Electrical brainstem stimulation",
author = "Z. Szel{\'e}nyi and Eugen Zeisberger and Kurt Br{\"u}ck",
year = "1977",
month = "1",
doi = "10.1007/BF00707940",
language = "English",
volume = "370",
pages = "19--23",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - A hypothalamic alpha-adrenergic mechanism mediating the thermogenic response to electrical stimulation of the lower brainstem in the guinea pig

AU - Szelényi, Z.

AU - Zeisberger, Eugen

AU - Brück, Kurt

PY - 1977/1

Y1 - 1977/1

N2 - Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient temperature ESLB elicited a thermogenic response resembling that evoked by microinjection of noradrenaline into the hypothalamus. The response consisted of a rise in oxygen uptake (to more than 50% of the resting value) and of body temperatures, especially of the interscapular adipose tissue. In some cases shivering was also evoked. The thermogenic response to ESLB was completely blocked by additional microinjection of an adrenergic alpha-receptor blocker, phentolamine, into the hypothalamic area where the noradrenergic fibres were presumed to terminate. Subsequent intrahypothalamic injection of noradrenaline, which had formerly been shown to restore the decreased responses to repeated ESLB, failed to restore the effectiveness of ESLB after phentolamine. It is concluded that the thermogenic responses to ESLB are mediated by a noradrenergic pathway ascending to the hypothalamus and not by direct stimulation of efferent pathways controlling the peripheral target system. The hypothalamic transmission can be prevented by an alpha-adrenergic blockade.

AB - Electrical stimulation of the lower brain stem (ESLB) at sites presumed to be parts of the ascending noradrenergic system was carried out in unanaesthetized young guinea pigs. At neutral ambient temperature ESLB elicited a thermogenic response resembling that evoked by microinjection of noradrenaline into the hypothalamus. The response consisted of a rise in oxygen uptake (to more than 50% of the resting value) and of body temperatures, especially of the interscapular adipose tissue. In some cases shivering was also evoked. The thermogenic response to ESLB was completely blocked by additional microinjection of an adrenergic alpha-receptor blocker, phentolamine, into the hypothalamic area where the noradrenergic fibres were presumed to terminate. Subsequent intrahypothalamic injection of noradrenaline, which had formerly been shown to restore the decreased responses to repeated ESLB, failed to restore the effectiveness of ESLB after phentolamine. It is concluded that the thermogenic responses to ESLB are mediated by a noradrenergic pathway ascending to the hypothalamus and not by direct stimulation of efferent pathways controlling the peripheral target system. The hypothalamic transmission can be prevented by an alpha-adrenergic blockade.

KW - Adrenergic alpha-receptor blocking agents

KW - Central control of thermogenesis

KW - Central noradrenergic pathways

KW - Electrical brainstem stimulation

UR - http://www.scopus.com/inward/record.url?scp=0017687439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017687439&partnerID=8YFLogxK

U2 - 10.1007/BF00707940

DO - 10.1007/BF00707940

M3 - Article

C2 - 197481

AN - SCOPUS:0017687439

VL - 370

SP - 19

EP - 23

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 1

ER -