A hybrid cellular automaton model of tumor-induced angiogenesis

Tamás Gönczy, Dávid Csercsik, L. Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several studies have shown that tumor growth is highly dependent on the presence of a mature vascular network, thus therapies that inhibit tumor-induced vascularization mechanisms can play a crucial role in the fight against cancer. In order to develop effective targeted therapies and individualized treatments, we have to consider the type and molecular background of vascularization mechanisms and the stage of the disease. In this paper a hybrid cellular automaton model of pathological angiogenesis is presented, that explicitly describes the pathophysiological processes taking place during tumor progression. By simulating tumor cell proliferation and necrosis, the diffusion of proangiogenic factors and nutrients, sprouting angiogenesis and alternative vascularization mechanisms, the model is able to reproduce similar capillary networks and characteristic structures compared to results obtained in vivo.

Original languageEnglish
Title of host publication2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-6
Number of pages6
ISBN (Electronic)9781538622049
DOIs
Publication statusPublished - Jul 3 2018
Event21st IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - Cluj-Napoca, Romania
Duration: May 24 2018May 26 2018

Other

Other21st IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018
CountryRomania
CityCluj-Napoca
Period5/24/185/26/18

Fingerprint

Hybrid Automata
Angiogenesis
Cellular Automaton Model
Cellular automata
Hybrid Model
Tumors
Tumor
Therapy
Necrosis
Cell Proliferation
Tumor Growth
Nutrients
Progression
Cancer
Cell proliferation
Dependent
Alternatives
Model

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Science Applications
  • Safety, Risk, Reliability and Quality
  • Control and Optimization

Cite this

Gönczy, T., Csercsik, D., & Kovács, L. (2018). A hybrid cellular automaton model of tumor-induced angiogenesis. In 2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings (pp. 1-6). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/AQTR.2018.8402781

A hybrid cellular automaton model of tumor-induced angiogenesis. / Gönczy, Tamás; Csercsik, Dávid; Kovács, L.

2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-6.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gönczy, T, Csercsik, D & Kovács, L 2018, A hybrid cellular automaton model of tumor-induced angiogenesis. in 2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings. Institute of Electrical and Electronics Engineers Inc., pp. 1-6, 21st IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018, Cluj-Napoca, Romania, 5/24/18. https://doi.org/10.1109/AQTR.2018.8402781
Gönczy T, Csercsik D, Kovács L. A hybrid cellular automaton model of tumor-induced angiogenesis. In 2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-6 https://doi.org/10.1109/AQTR.2018.8402781
Gönczy, Tamás ; Csercsik, Dávid ; Kovács, L. / A hybrid cellular automaton model of tumor-induced angiogenesis. 2018 IEEE International Conference on Automation, Quality and Testing, Robotics, AQTR 2018 - THETA 21st Edition, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1-6
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