A human genomic sequence highly homologous to the 3′-untranslated region of rat uricase mRNA

Kiyoto Motojima, S. Goto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A human genomic sequence was isolated from a library using a rat uricase cDNA probe. Sequence analysis has shown that it is highly homologous to the 3′-untranslated region of rat uricase mRNA. Total loss of uricase activity in human is, therefore, not due to total loss of the gene. Discovery of high degree of conservation of the non-coding region of the gene would be of great interest as we attempt to learn the process of gene evolution.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume155
Issue number3
DOIs
Publication statusPublished - Sep 30 1988

Fingerprint

Urate Oxidase
3' Untranslated Regions
Sequence Homology
Rats
Genes
Messenger RNA
Human Activities
Libraries
Sequence Analysis
Conservation
Complementary DNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A human genomic sequence highly homologous to the 3′-untranslated region of rat uricase mRNA. / Motojima, Kiyoto; Goto, S.

In: Biochemical and Biophysical Research Communications, Vol. 155, No. 3, 30.09.1988, p. 1266-1270.

Research output: Contribution to journalArticle

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