A high-yielding synthesis and kinetics of glycine formation from monochloroacetic acid and NH3 in the presence of hexamethylenetetramine

Lajos Gulyás, György Deák, Sándor Kéki, Róbert Horváth, Miklós Zsuga

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Glycine was synthesized with high yield (>98 %) from ammonia and monochloroacetic acid in the presence of hexamethylenetetramine in an aqueous solution. Hexamethylenetetramine accelerates the reaction between monochloroacetic acid and ammonia, the undesirable side-reactions, such as formation of iminodiacetic acid are suppressed, thus glycine can be obtained with high yield. On the basis of detailed kinetic investigations the apparent rate constants and the reaction mechanism are also described.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalACH - Models in Chemistry
Issue number4
Publication statusPublished - Dec 1 2000


ASJC Scopus subject areas

  • Chemistry(all)

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