A high-yielding synthesis and kinetics of glycine formation from monochloroacetic acid and NH3 in the presence of hexamethylenetetramine

Lajos Gulyás, G. Deák, S. Kéki, Róbert Horváth, M. Zsuga

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Abstract

Glycine was synthesized with high yield (>98 %) from ammonia and monochloroacetic acid in the presence of hexamethylenetetramine in an aqueous solution. Hexamethylenetetramine accelerates the reaction between monochloroacetic acid and ammonia, the undesirable side-reactions, such as formation of iminodiacetic acid are suppressed, thus glycine can be obtained with high yield. On the basis of detailed kinetic investigations the apparent rate constants and the reaction mechanism are also described.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalACH - Models in Chemistry
Volume137
Issue number4
Publication statusPublished - 2000

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Methenamine
Ammonia
Glycine
Kinetics
Rate constants
chloroacetic acid
iminodiacetic acid

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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abstract = "Glycine was synthesized with high yield (>98 {\%}) from ammonia and monochloroacetic acid in the presence of hexamethylenetetramine in an aqueous solution. Hexamethylenetetramine accelerates the reaction between monochloroacetic acid and ammonia, the undesirable side-reactions, such as formation of iminodiacetic acid are suppressed, thus glycine can be obtained with high yield. On the basis of detailed kinetic investigations the apparent rate constants and the reaction mechanism are also described.",
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T1 - A high-yielding synthesis and kinetics of glycine formation from monochloroacetic acid and NH3 in the presence of hexamethylenetetramine

AU - Gulyás, Lajos

AU - Deák, G.

AU - Kéki, S.

AU - Horváth, Róbert

AU - Zsuga, M.

PY - 2000

Y1 - 2000

N2 - Glycine was synthesized with high yield (>98 %) from ammonia and monochloroacetic acid in the presence of hexamethylenetetramine in an aqueous solution. Hexamethylenetetramine accelerates the reaction between monochloroacetic acid and ammonia, the undesirable side-reactions, such as formation of iminodiacetic acid are suppressed, thus glycine can be obtained with high yield. On the basis of detailed kinetic investigations the apparent rate constants and the reaction mechanism are also described.

AB - Glycine was synthesized with high yield (>98 %) from ammonia and monochloroacetic acid in the presence of hexamethylenetetramine in an aqueous solution. Hexamethylenetetramine accelerates the reaction between monochloroacetic acid and ammonia, the undesirable side-reactions, such as formation of iminodiacetic acid are suppressed, thus glycine can be obtained with high yield. On the basis of detailed kinetic investigations the apparent rate constants and the reaction mechanism are also described.

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