Hemorheology is the science of flow properties of cellular and plasmatic compounds of blood and also the vessel wall connected to it. Major determinants of blood viscosity such as plasma viscosity, fibrinogen concentration, hematocrit red blood cell deformability and red blood cell aggregation are changing sensitively in numerous pathophysiological processes; therefore the determination of these factors can serve important information in the research field using experimental animal models. The microrheological parameters (red blood cell deformability and red blood cell aggregation) have traceable indicator values in sepsis, inflammation processes and during ischemia-reperfusion. Also in case of animal experiments the species and gender differences of micro-rheological values are becoming more obvious. It is important to take these under consideration during planning or executing experiments and also during evaluating the results. The comparative methodical investigations, the standardization of blood sampling and handling are important from the aspect of animal care principles because the not proper methodological background can significantly influence the results. The investigations of hemorheological parameters based on the standards made for the actual laboratory animal species and the modern laboratory methodologies are suggestible for biomedical and veterinary science researches.
|Number of pages||8|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Nov 7 2011|
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