A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas

Anikó Angyal, András Demjén, J. Wölfling, L. Puskás, Iván Kanizsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N′-multisubstituted (thio)ureas were obtained in up to 85% yield.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 3 2018

Keywords

  • Isocyanide
  • Multicomponent reaction
  • N-chloro amine
  • Thiourea
  • Urea

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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