A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas

Anikó Angyal, András Demjén, J. Wölfling, L. Puskás, Iván Kanizsai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N′-multisubstituted (thio)ureas were obtained in up to 85% yield.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 3 2018

Fingerprint

Thiourea
Cyanides
Urea
Small Molecule Libraries
Microwaves
Amines
Derivatives

Keywords

  • Isocyanide
  • Multicomponent reaction
  • N-chloro amine
  • Thiourea
  • Urea

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas. / Angyal, Anikó; Demjén, András; Wölfling, J.; Puskás, L.; Kanizsai, Iván.

In: Tetrahedron Letters, Vol. 59, No. 1, 03.01.2018, p. 54-57.

Research output: Contribution to journalArticle

@article{9411bbca83c34d0db9f04622e3a9432c,
title = "A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas",
abstract = "A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N′-multisubstituted (thio)ureas were obtained in up to 85{\%} yield.",
keywords = "Isocyanide, Multicomponent reaction, N-chloro amine, Thiourea, Urea",
author = "Anik{\'o} Angyal and Andr{\'a}s Demj{\'e}n and J. W{\"o}lfling and L. Pusk{\'a}s and Iv{\'a}n Kanizsai",
year = "2018",
month = "1",
day = "3",
doi = "10.1016/j.tetlet.2017.11.053",
language = "English",
volume = "59",
pages = "54--57",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas

AU - Angyal, Anikó

AU - Demjén, András

AU - Wölfling, J.

AU - Puskás, L.

AU - Kanizsai, Iván

PY - 2018/1/3

Y1 - 2018/1/3

N2 - A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N′-multisubstituted (thio)ureas were obtained in up to 85% yield.

AB - A one-pot, isocyanide based multicomponent protocol was presented starting from secondary amines towards (thio)urea derivatives and utilized for the construction of a diverse 27-membered chemical library. Following a green compatible microwave assisted condition, the formed N,N′-multisubstituted (thio)ureas were obtained in up to 85% yield.

KW - Isocyanide

KW - Multicomponent reaction

KW - N-chloro amine

KW - Thiourea

KW - Urea

UR - http://www.scopus.com/inward/record.url?scp=85038845400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038845400&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2017.11.053

DO - 10.1016/j.tetlet.2017.11.053

M3 - Article

VL - 59

SP - 54

EP - 57

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 1

ER -