A Golgi and a combined Golgi/GABA immunogold study of local circuit neurons in the homing pigeon hippocampus

T. Tömböl, D. C. Davies, A. Németh, A. Alpár, T. Sebestény

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three types of local circuit neurons have recently been reported in the homing pigeon hippocampus. The principal type appears to be constituted by the medium-sized angular or ovoid local circuit neurons that occur in all layers of the hippocampus. The current Golgi study has revealed that these neurons can be classified according to their axonal arborisation extension: (1) in all directions, (2) principally medio-laterally, or (3) dorso-ventrally. The local circuit neurons with dorsoventral axon arborisation are present only in the subpyramidal layer. Serial sections of a Golgi-impregnated medium-sized, multiangular local circuit neuron in the pyramidal layer and a small, ovoid neuron in the suprapyramidal layer were investigated in the electron microscope. Some of these sections were processed for GABA immunogold cytochemistry. The soma and large dendrites of both neurons displayed GABA immunogold labelling. On the soma of medium-sized local circuit neuron there were numerous terminals; on the soma of the small one relatively fewer terminals were observed. The terminals contained round and/or flat synaptic vesicles. The long axonal branches of the neurons exhibited varicosities containing flattened or pleomorphic vesicles. Axo-dendritic, axo-somatic and a few axo-axonic synapses were observed. The large dense axon arborisation field of medium-sized local circuit neurons is properly situated to modulate intrinsic hippocampal activity and that of the small local circuit neurons is well situated to modulate the hippocampal input in the suprapyramidal layer.

Original languageEnglish
Pages (from-to)181-196
Number of pages16
JournalAnatomy and Embryology
Volume201
Issue number3
Publication statusPublished - 2000

Fingerprint

Columbidae
gamma-Aminobutyric Acid
Hippocampus
Neurons
Carisoprodol
Axons
GABAergic Neurons
Histocytochemistry
Synaptic Vesicles
Pyramidal Cells
Dendrites
Synapses
Electrons

Keywords

  • GABA immunostaining
  • Hippocampus
  • Homing pigeon
  • Local circuit neurons

ASJC Scopus subject areas

  • Anatomy
  • Developmental Biology
  • Cell Biology
  • Embryology

Cite this

A Golgi and a combined Golgi/GABA immunogold study of local circuit neurons in the homing pigeon hippocampus. / Tömböl, T.; Davies, D. C.; Németh, A.; Alpár, A.; Sebestény, T.

In: Anatomy and Embryology, Vol. 201, No. 3, 2000, p. 181-196.

Research output: Contribution to journalArticle

Tömböl, T. ; Davies, D. C. ; Németh, A. ; Alpár, A. ; Sebestény, T. / A Golgi and a combined Golgi/GABA immunogold study of local circuit neurons in the homing pigeon hippocampus. In: Anatomy and Embryology. 2000 ; Vol. 201, No. 3. pp. 181-196.
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