A global analysis of Y-chromosomal haplotype diversity for 23 STR loci

Josephine Purps, Sabine Siegert, Sascha Willuweit, Marion Nagy, Cíntia Alves, Renato Salazar, Sheila M.T. Angustia, Lorna H. Santos, Katja Anslinger, Birgit Bayer, Qasim Ayub, Wei Wei, Yali Xue, Chris Tyler-Smith, Miriam Baeta Bafalluy, Begoña Martínez-Jarreta, Balazs Egyed, Beate Balitzki, Sibylle Tschumi, David BallardDenise Syndercombe Court, Xinia Barrantes, Gerhard Bäßler, Tina Wiest, Burkhard Berger, Harald Niederstätter, Walther Parson, Carey Davis, Bruce Budowle, Helen Burri, Urs Borer, Christoph Koller, Elizeu F. Carvalho, Patricia M. Domingues, Wafaa Takash Chamoun, Michael D. Coble, Carolyn R. Hill, Daniel Corach, Mariela Caputo, Maria E. D'Amato, Sean Davison, Ronny Decorte, Maarten H.D. Larmuseau, Claudio Ottoni, Olga Rickards, Di Lu, Chengtao Jiang, Tadeusz Dobosz, Anna Jonkisz, William E. Frank, Ivana Furac, Christian Gehrig, Vincent Castella, Branka Grskovic, Cordula Haas, Jana Wobst, Gavrilo Hadzic, Katja Drobnic, Katsuya Honda, Yiping Hou, Di Zhou, Yan Li, Shengping Hu, Shenglan Chen, Uta Dorothee Immel, Rüdiger Lessig, Zlatko Jakovski, Tanja Ilievska, Anja E. Klann, Cristina Cano García, Peter De Knijff, Thirsa Kraaijenbrink, Aikaterini Kondili, Penelope Miniati, Maria Vouropoulou, Lejla Kovacevic, Damir Marjanovic, Iris Lindner, Issam Mansour, Mouayyad Al-Azem, Ansar El Andari, Miguel Marino, Sandra Furfuro, Laura Locarno, Pablo Martín, Gracia M. Luque, Antonio Alonso, Luís Souto Miranda, Helena Moreira, Natsuko Mizuno, Yasuki Iwashima, Rodrigo S.Moura Neto, Tatiana L.S. Nogueira, Rosane Silva, Marina Nastainczyk-Wulf, Jeanett Edelmann, Michael Kohl, Shengjie Nie, Xianping Wang, Baowen Cheng, Carolina Núñez, Marian Martínez De Pancorbo, Jill K. Olofsson, Niels Morling, Valerio Onofri, Adriano Tagliabracci, Horolma Pamjav, Antonia Volgyi, Gusztav Barany, Ryszard Pawlowski, Agnieszka Maciejewska, Susi Pelotti, Witold Pepinski, Monica Abreu-Glowacka, Christopher Phillips, Jorge Cárdenas, Danel Rey-Gonzalez, Antonio Salas, Francesca Brisighelli, Cristian Capelli, Ulises Toscanini, Andrea Piccinini, Marilidia Piglionica, Stefania L. Baldassarra, Rafal Ploski, Magdalena Konarzewska, Emila Jastrzebska, Carlo Robino, Antti Sajantila, Jukka U. Palo, Evelyn Guevara, Jazelyn Salvador, Maria Corazon De Ungria, Jae Joseph Russell Rodriguez, Ulrike Schmidt, Nicola Schlauderer, Pekka Saukko, Peter M. Schneider, Miriam Sirker, Kyoung Jin Shin, Yu Na Oh, Iulia Skitsa, Alexandra Ampati, Tobi Gail Smith, Lina Solis De Calvit, Vlastimil Stenzl, Thomas Capal, Andreas Tillmar, Helena Nilsson, Stefania Turrina, Domenico De Leo, Andrea Verzeletti, Venusia Cortellini, Jon H. Wetton, Gareth M. Gwynne, Mark A. Jobling, Martin R. Whittle, Denilce R. Sumita, Paulina Wolańska-Nowak, Rita Y.Y. Yong, Michael Krawczak, Michael Nothnagel, Lutz Roewer

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.

Original languageEnglish
Pages (from-to)12-23
Number of pages12
JournalForensic Science International: Genetics
Volume12
DOIs
Publication statusPublished - Sep 2014

Keywords

  • AMOVA
  • Database
  • Discriminatory power
  • Gene diversity
  • Population structure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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  • Cite this

    Purps, J., Siegert, S., Willuweit, S., Nagy, M., Alves, C., Salazar, R., Angustia, S. M. T., Santos, L. H., Anslinger, K., Bayer, B., Ayub, Q., Wei, W., Xue, Y., Tyler-Smith, C., Bafalluy, M. B., Martínez-Jarreta, B., Egyed, B., Balitzki, B., Tschumi, S., ... Roewer, L. (2014). A global analysis of Y-chromosomal haplotype diversity for 23 STR loci. Forensic Science International: Genetics, 12, 12-23. https://doi.org/10.1016/j.fsigen.2014.04.008